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New Modelling On Bushfires Shows How They Really Burn Through An Area, Philip J. Zylstra Jan 2016

New Modelling On Bushfires Shows How They Really Burn Through An Area, Philip J. Zylstra

Faculty of Science, Medicine and Health - Papers: part A

Bushfires in Australia can have a devastating impact on an environment and destroy homes and lives, so any effort to prevent them is a welcome move.

But the way that we have traditionally understood bushfires and forest flammability in Australia is not up to the challenges of our changing climate. Thankfully, a new approach is making sense of the confusion by looking at the plants themselves.


A Method Of Providing Engaging Formative Feedback To Large Cohort First-Year Physiology And Anatomy Students, Katrina Weston-Green, Margaret Christina Wallace Jan 2016

A Method Of Providing Engaging Formative Feedback To Large Cohort First-Year Physiology And Anatomy Students, Katrina Weston-Green, Margaret Christina Wallace

Faculty of Science, Medicine and Health - Papers: part A

A growing body of evidence demonstrates a critical role for effective, meaningful feedback to enhance student learning. Effective feedback can become part of the learning cycle that is not only a learning opportunity for the student but can also be used to inform the teacher and ongoing curriculum development. Feedback is considered particularly important during the first year of university and can even be viewed as a retention strategy that can help attenuate student performance anxieties and solidify perceptions of academic support. Unfortunately, the provision of individualized, timely feedback can be particularly challenging in first-year courses as they tend to …


Flowers In Australia: Phytochemical Studies On The Illawarra Flame Tree And Alstonville, Rudi Hendra, Paul A. Keller Jan 2016

Flowers In Australia: Phytochemical Studies On The Illawarra Flame Tree And Alstonville, Rudi Hendra, Paul A. Keller

Faculty of Science, Medicine and Health - Papers: part A

The first reported phytochemical studies on two species of flowers in Australia enabled the identification of six secondary metabolites from Illawarra flame tree flower (Brachychiton acerifolius) and seven secondary metabolites from the flowers of the Alstonville (Tibouchina lepidota). Pelargonidin 3-(6-coumarylglucoside)-5-(6-acetylglucoside) was found to be responsible for the red colour of B. acerifolius, whereas malvidin 3-(coumarylglucoside)-5-(acetylxyloside) was responsible for the purple colour of (T. lepidota) flowers. (2S)-4,5-Dihydroxyflavanone 7-O-β-d-glucuronide methyl ester was isolated for the first time from B. acerifolius, and its absolute configuration was determined by circular dichroism spectroscopy. Some of the traditional uses of B. acerifolius could also be correlated …


Disinhibition-Like Behavior In A P301s Mutant Tau Transgenic Mouse Model Of Frontotemporal Dementia, Magdalena Przybyla, Claire H. Stevens, Julia Van Der Hoven, Anne Harasta, Mian Bi, Arne Ittner, Annika Van Hummel, John R. Hodges, Olivier Piguet, Tim Karl, Michael Kassiou, Gary D. Housley, Yazi D. Ke, Lars M. Ittner, Janet Van Eersel Jan 2016

Disinhibition-Like Behavior In A P301s Mutant Tau Transgenic Mouse Model Of Frontotemporal Dementia, Magdalena Przybyla, Claire H. Stevens, Julia Van Der Hoven, Anne Harasta, Mian Bi, Arne Ittner, Annika Van Hummel, John R. Hodges, Olivier Piguet, Tim Karl, Michael Kassiou, Gary D. Housley, Yazi D. Ke, Lars M. Ittner, Janet Van Eersel

Faculty of Science, Medicine and Health - Papers: part A

Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.


Toward A Chemical Reanalysis In A Coupled Chemistry-Climate Model: An Evaluation Of Mopitt Co Assimilation And Its Impact On Tropospheric Composition, B Gaubert, A F. Arellano, J Barré, H M. Worden, Louisa Emmons, S Tilmes, Rebecca R. Buchholz, F Vitt, K Raeder, N Collins, J L. Anderson, Christine Wiedinmyer, S Martinez Alonso, D P. Edwards, M Andreae, James W. Hannigan, Christof Petri, Kimberly Strong, Nicholas B. Jones Jan 2016

Toward A Chemical Reanalysis In A Coupled Chemistry-Climate Model: An Evaluation Of Mopitt Co Assimilation And Its Impact On Tropospheric Composition, B Gaubert, A F. Arellano, J Barré, H M. Worden, Louisa Emmons, S Tilmes, Rebecca R. Buchholz, F Vitt, K Raeder, N Collins, J L. Anderson, Christine Wiedinmyer, S Martinez Alonso, D P. Edwards, M Andreae, James W. Hannigan, Christof Petri, Kimberly Strong, Nicholas B. Jones

Faculty of Science, Medicine and Health - Papers: part A

We examine in detail a 1 year global reanalysis of carbon monoxide (CO) that is based on joint assimilation of conventional meteorological observations and Measurement of Pollution in The Troposphere (MOPITT) multispectral CO retrievals in the Community Earth System Model (CESM). Our focus is to assess the impact to the chemical system when CO distribution is constrained in a coupled full chemistry-climate model like CESM. To do this, we first evaluate the joint reanalysis (MOPITT Reanalysis) against four sets of independent observations and compare its performance against a reanalysis with no MOPITT assimilation (Control Run). We then investigate the CO …


Compositional Data Analysis As A Robust Tool To Delineate Hydrochemical Facies Within And Between Gas-Bearing Aquifers, D D.R Owen, V Pawlowsky-Glahn, J J. Egozcue, A Buccianti, John M. Bradd Jan 2016

Compositional Data Analysis As A Robust Tool To Delineate Hydrochemical Facies Within And Between Gas-Bearing Aquifers, D D.R Owen, V Pawlowsky-Glahn, J J. Egozcue, A Buccianti, John M. Bradd

Faculty of Science, Medicine and Health - Papers: part A

Isometric log ratios of proportions of major ions, derived from intuitive sequential binary partitions, are used to characterize hydrochemical variability within and between coal seam gas (CSG) and surrounding aquifers in a number of sedimentary basins in the USA and Australia. These isometric log ratios are the coordinates corresponding to an orthonormal basis in the sample space (the simplex). The characteristic proportions of ions, as described by linear models of isometric log ratios, can be used for a mathematical-descriptive classification of water types. This is a more informative and robust method of describing water types than simply classifying a water …


Three Arcs: Observations On The Archaeology Of The Elands Bay And Northern Cederberg Landscapes, Alex Mackay Jan 2016

Three Arcs: Observations On The Archaeology Of The Elands Bay And Northern Cederberg Landscapes, Alex Mackay

Faculty of Science, Medicine and Health - Papers: part A

The area around Elands Bay and the adjacent interior landscapes west of the Doring River have been subject to intense archaeological investigation over the last ~50 years. The result is a region with great depth and diversity of archaeological information. In this paper I discuss three general observations that arise from the integration of data across this region. The first is that redundancy in site occupation is limited: even where many sites are excavated in a small area, understanding of the regional sequence cannot be assumed to be complete. The second is that humans did not live in rock shelters: …


Master Athletes Are Extending The Limits Of Human Endurance, Romuald Lepers, Paul J. Stapley Jan 2016

Master Athletes Are Extending The Limits Of Human Endurance, Romuald Lepers, Paul J. Stapley

Faculty of Science, Medicine and Health - Papers: part A

Theincreasedparticipationofmasterathletes(i.e.,>40yearsold)inenduranceandultra-enduranceevents(>6hduration)overthepastfewdecadeshasbeenaccompaniedbyanimprovementintheirperformancesatamuchfasterratethantheiryoungercounterparts.Agingdoeshoweverresultinadecreaseinoverallenduranceperformance.Suchage-relateddeclinesinperformancedependuponthemodesoflocomotion,eventduration,andgenderoftheparticipant.Forexample,smallerage-relateddeclinesincyclingperformancethaninrunningandswimminghavebeendocumented.Therelativestabilityofgenderdifferencesobservedacrosstheagessuggeststhattheage-relateddeclinesinphysiologicalfunctiondidnotdifferbetweenmalesandfemales.Amongthemainphysiologicaldeterminantsofenduranceperformance,themaximaloxygenconsumption(VO2max)appearstobetheparameterthatismostalteredbyage.ExerciseeconomyandtheexerciseintensityatwhichahighfractionofVO2maxcanbesustained(i.e.,lactatethreshold),seemtodeclinetoalesserextentwithadvancingage.Theabilitytomaintainahighexercise-trainingstimuluswithadvancingageisemergingasthesinglemostimportantmeansoflimitingtherateofdeclineinenduranceperformance.Byconstantlyextendingthelimitsof(ultra)-endurance,masterathletesthereforerepresentanimportantinsightintotheabilityofhumanstomaintainphysicalperformanceandphysiologicalfunctionwithadvancingage.


First Tephrostratigraphic Results Of The Deep Site Record From Lake Ohrid (Macedonia And Albania), Niklas Leicher, Giovanni Zanchetta, Roberto Sulpizio, Biagio Giaccio, Bernd Wagner, Sebastien Nomade, Alexander Francke, Paola Del Carlo Jan 2016

First Tephrostratigraphic Results Of The Deep Site Record From Lake Ohrid (Macedonia And Albania), Niklas Leicher, Giovanni Zanchetta, Roberto Sulpizio, Biagio Giaccio, Bernd Wagner, Sebastien Nomade, Alexander Francke, Paola Del Carlo

Faculty of Science, Medicine and Health - Papers: part A

A tephrostratigraphic record covering the Marine Isotope Stages (MIS) 1-15 was established for the DEEP site record of Lake Ohrid (Macedonia and Albania). Major element analyses (energy dispersive spectroscopy (EDS) and wavelength-dispersive spectroscopy (WDS)) were carried out on juvenile fragments extracted from 12 tephra layers (OH-DP-0115 to OH-DP-2060). The geochemical analyses of the glass shards of all of these layers suggest an origin in the Italian volcanic provinces. They include the Y-3 (OH-DP-0115, 26.68-29.42 ka cal BP), the Campanian Ignimbrite-Y-5 (OH-DP-0169, 39.6 ± 0.1 ka), and the X-6 (OH-DP-0404, 109 ± 2 ka) from the Campanian volcanoes, the P-11 of …


Environmental Control On The Occurrence Of High-Coercivity Magnetic Minerals And Formation Of Iron Sulfides In A 640 Ka Sediment Sequence From Lake Ohrid (Balkans), Janna Just, Norbert R. Nowaczyk, Leonardo Sagnotti, Alexander Francke, Hendrik Vogel, Jack H. Lacey, Bernd Wagner Jan 2016

Environmental Control On The Occurrence Of High-Coercivity Magnetic Minerals And Formation Of Iron Sulfides In A 640 Ka Sediment Sequence From Lake Ohrid (Balkans), Janna Just, Norbert R. Nowaczyk, Leonardo Sagnotti, Alexander Francke, Hendrik Vogel, Jack H. Lacey, Bernd Wagner

Faculty of Science, Medicine and Health - Papers: part A

The bulk magnetic mineral record from Lake Ohrid, spanning the past 637 kyr, reflects large-scale shifts in hydrological conditions, and, superimposed, a strong signal of environmental conditions on glacial-interglacial and millennial timescales. A shift in the formation of early diagenetic ferrimagnetic iron sulfides to siderites is observed around 320 ka. This change is probably associated with variable availability of sulfide in the pore water. We propose that sulfate concentrations were significantly higher before  ∼  320 ka, due to either a higher sulfate flux or lower dilution of lake sulfate due to a smaller water volume. Diagenetic iron minerals appear more …


Access To Rehabilitation Services: A 'Fair Go' For Individuals Living With A Dementia, Victoria Traynor, Loren De Vries Jan 2016

Access To Rehabilitation Services: A 'Fair Go' For Individuals Living With A Dementia, Victoria Traynor, Loren De Vries

Faculty of Science, Medicine and Health - Papers: part A

Similar to other Western countries, approximately nine per cent of Australians aged over 65 are living with a dementia and for those aged over 85 the prevalence rate rises to up to 30 per cent. As the ageing population increases, the prevalence of dementia will increase (Guideline Adaptation Committee, 2016). It is doubtless an important healthcare issue. In the past 10 years, since the Australian Government published its first National Framework for Action on Dementia and the nomination of dementia as a National Health Priority, dementia care has achieved never imagined improvements. Dementiaspecific research and educational initiatives by the Dementia …


A New Species Of Celebochoerus (Suidae, Mammalia) From The Philippines And The Paleobiogeography Of The Genus Celebochoerus Hooijer, 1948, Thomas Ingicco, Gerrit D. Van Den Bergh, John De Vos, Abigael Castro, Noel Amano, Angel Bautista Jan 2016

A New Species Of Celebochoerus (Suidae, Mammalia) From The Philippines And The Paleobiogeography Of The Genus Celebochoerus Hooijer, 1948, Thomas Ingicco, Gerrit D. Van Den Bergh, John De Vos, Abigael Castro, Noel Amano, Angel Bautista

Faculty of Science, Medicine and Health - Papers: part A

Celebochoerus is a unique suid having extremely large upper tusks, and which was to date only known from the Pliocene-Pleistocene of Sulawesi Island in Indonesia. Here, we report on the discovery of a canine fragment referable to Celebochoerus from the Cagayan Valley of Luzon, Northern Philippines. We name a new species, Celebochoerus cagayanensis nov. sp., which differs from the Sulawesi species Celebochoerus heekereni in having mesial and distal enamel bands on the upper canines. We see these characteristics as symplesiomorphic in suids and propose a migration route from the Philippines to Sulawesi, possibly out of Taiwan, which would have occurred …


Making Sense Of Critical Participatory Action Research. Reflections On The Action Research Planner: Doing Critical Participatory Action Research, Maria T. Mackay Jan 2016

Making Sense Of Critical Participatory Action Research. Reflections On The Action Research Planner: Doing Critical Participatory Action Research, Maria T. Mackay

Faculty of Science, Medicine and Health - Papers: part A

After immersing myself in The Research Planner: Doing Critical Participatory Action Research, I believe I have a better understanding of participatory action research and its relationship to the work of Habermas. I feel it has enabled me to align my values and beliefs with Habermas and action research's philosophical underpinnings within the critical theory paradigm. For me this book has clarified how communicative spaces, the theory of communicative action and public spheres are related to participatory methodologies.


Energetics Of Communal Roosting In Chestnut-Crowned Babblers: Implications For Group Dynamics And Breeding Phenology, Mark A. Chappell, William A. Buttemer, Andrew Russell Jan 2016

Energetics Of Communal Roosting In Chestnut-Crowned Babblers: Implications For Group Dynamics And Breeding Phenology, Mark A. Chappell, William A. Buttemer, Andrew Russell

Faculty of Science, Medicine and Health - Papers: part A

For many endotherms, communal roosting saves energy in cold conditions, but how this might affect social dynamics or breeding phenology is not well understood. Using chestnut-crowned babblers (Pomatostomus ruficeps), we studied the effects of nest use and group size on roosting energy costs. These 50 g cooperatively breeding passerine birds of outback Australia breed from late winter to early summer and roost in huddles of up to 20 in single-chambered nests. We measured babbler metabolism at three ecologically relevant temperatures: 5°C (similar to minimum nighttime temperatures during early breeding), 15°C (similar to nighttime temperatures during late breeding) and 28°C (thermal …


A Rapid Burst In Hotspot Motion Through The Interaction Of Tectonics And Deep Mantle Flow, Rakib Hassan, R Dietmar Muller, Michael Gurnis, Simon E. Williams, Nicolas Flament Jan 2016

A Rapid Burst In Hotspot Motion Through The Interaction Of Tectonics And Deep Mantle Flow, Rakib Hassan, R Dietmar Muller, Michael Gurnis, Simon E. Williams, Nicolas Flament

Faculty of Science, Medicine and Health - Papers: part A

Volcanic hotspot tracks featuring linear progressions in the age of volcanism are typical surface expressions of plate tectonic movement on top of narrow plumes of hot material within Earth's mantle1. Seismic imaging reveals that these plumes can be of deep origin2-probably rooted on thermochemical structures in the lower mantle3, 4, 5, 6. Although palaeomagnetic and radiometric age data suggest that mantle flow can advect plume conduits laterally7, 8, the flow dynamics underlying the formation of the sharp bend occurring only in the Hawaiian-Emperor hotspot track in the Pacific Ocean remains enigmatic. Here we present palaeogeographically constrained numerical models of thermochemical …


An Investigation Of Future Fuel Load And Fire Weather In Australia, Hamish Clarke, Andy Pitman, Jatin Kala, Claire C. Carouge, Vanessa E. Haverd, Jason P. Evans Jan 2016

An Investigation Of Future Fuel Load And Fire Weather In Australia, Hamish Clarke, Andy Pitman, Jatin Kala, Claire C. Carouge, Vanessa E. Haverd, Jason P. Evans

Faculty of Science, Medicine and Health - Papers: part A

We present an assessment of the impact of future climate change on two key drivers of fire risk in Australia, fire weather and fuel load. Fire weather conditions are represented by the McArthur Forest Fire Danger Index (FFDI), calculated from a 12-member regional climate model ensemble. Fuel load is predicted from net primary production, simulated using a land surface model forced by the same regional climate model ensemble. Mean annual fine litter is projected to increase across all ensemble members, by 1.2 to 1.7 t ha-1 in temperate areas, 0.3 to 0.5 t ha-1 in grassland areas and 0.7 to …


Unravelling The Glass Trade Bead Sequence From Magoro Hill, South Africa: Separating Pre-Seventeenth-Century Asian Imports From Later European Counterparts, Farahnaz Koleini, Linda C. Prinsloo, Wim M. Biemond, Philippe Colomban, Anh T. Ngo, Jan C. Boeyens, Maria M. Van Der Ryst, Koos Van Brakel Jan 2016

Unravelling The Glass Trade Bead Sequence From Magoro Hill, South Africa: Separating Pre-Seventeenth-Century Asian Imports From Later European Counterparts, Farahnaz Koleini, Linda C. Prinsloo, Wim M. Biemond, Philippe Colomban, Anh T. Ngo, Jan C. Boeyens, Maria M. Van Der Ryst, Koos Van Brakel

Faculty of Science, Medicine and Health - Papers: part A

Excavations conducted between 2010 and 2012 at Magoro Hill, a site in South Africa's Limpopo Province frequented or intermittently occupied by African farming communities since the first millennium AD, yielded a substantial glass bead assemblage. A selection of the beads was studied non-destructively by classifying them according to morphological attributes, supplemented by Raman analyses and XRF measurements. It became evident that a morphological classification of beads recovered from sites that include imports into Africa after the seventeenth century AD could be problematic due to apparent morphological similarities between earlier and later beads. This paper demonstrates the use and archaeological application …


Exaggerations And Caveats In Press Releases And Health-Related Science News, Petroc Sumner, Solveiga Vivian Griffiths, Jacky Boivin, Andrew Williams, Lewis Bott, Rachel Adams, Christos Venetis, Leanne Whelan, Bethan Hughes, Christopher D. Chambers Jan 2016

Exaggerations And Caveats In Press Releases And Health-Related Science News, Petroc Sumner, Solveiga Vivian Griffiths, Jacky Boivin, Andrew Williams, Lewis Bott, Rachel Adams, Christos Venetis, Leanne Whelan, Bethan Hughes, Christopher D. Chambers

Faculty of Science, Medicine and Health - Papers: part A

Background: Exaggerated or simplistic news is often blamed for adversely influencing public health. However, recent findings suggested many exaggerations were already present in university press releases, which scientists approve. Surprisingly, these exaggerations were not associated with more news coverage. Here we test whether these two controversial results also arise in press releases from prominent science and medical journals. We then investigate the influence of mitigating caveats in press releases, to test assumptions that caveats harm news interest or are ignored.

Methods and Findings Using: quantitative content analysis, we analyzed press releases (N = 534) on biomedical and health-related science issued …


Posaconazole Therapeutic Drug Monitoring In A Regional Hospital Setting, Patrick J. Lindsay, Stuart Bond, Ross Norris, Deborah Marriott, Spiros Miyakis Jan 2016

Posaconazole Therapeutic Drug Monitoring In A Regional Hospital Setting, Patrick J. Lindsay, Stuart Bond, Ross Norris, Deborah Marriott, Spiros Miyakis

Faculty of Science, Medicine and Health - Papers: part A

BACKGROUND: Posaconazole therapeutic drug monitoring (TDM) is recommended to promote effective antifungal prophylaxis, but its utility has yet to be optimized. Breakthrough invasive fungal infections have been reported with serum concentrations/L, but there is little evidence to determine the optimal serum concentration for efficacy or concentrations associated with toxicity. Challenges for effective monitoring are greater in settings without posaconazole TDM facilities because of the long turnaround time before receipt of results.

METHODS: Thirty-eight TDM episodes were performed on 18 patients in a regional center in Australia during a 30-month period. Australian guidelines recommend a trough serum concentration of ≥700 mcg/L. …


Is Delirium Being Detected In Emergency?, Victoria Traynor, Nicholas Cordato, Pippa Burns, Yun Xu, Nicole Britten, Kim Duncan, Loren Devries, Colleen Mckinnon Jan 2016

Is Delirium Being Detected In Emergency?, Victoria Traynor, Nicholas Cordato, Pippa Burns, Yun Xu, Nicole Britten, Kim Duncan, Loren Devries, Colleen Mckinnon

Faculty of Science, Medicine and Health - Papers: part A

Objective To report on the use of Delirium Care Pathways to screen for and recognise delirium by Aged Care Services in Emergency Teams (ASETs) at five metropolitan hospitals in New South Wales, Australia. Knowledge of delirium and the use of Delirium Care Pathways are vital to ensure that older people presenting with delirium receive best practice care. Methods An audit of 205 randomly selected medical records of clients over 65 years presenting to an ASET was conducted. Results Delirium was recorded in the medical records notes of four clients (2%). However, the auditors identified another 27 clients with symptoms of …


Ability Of The 4-D-Var Analysis Of The Gosat Besd Xco2 Retrievals To Characterize Atmospheric Co2 At Large And Synoptic Scales, Sébastien Massart, Anna Agustí-Panareda, Jens Heymann, Michael Buchwitz, Frédéric Chevallier, Maximilian Reuter, Michael Hilker, J P. Burrows, Nicholas M. Deutscher, D Feist, Frank Hase, Ralf Sussmann, Filip Desmet, Manvendra K. Dubey, David W. T Griffith, Rigel Kivi, Christof Petri, Matthias Schneider, Voltaire A. Velazco Jan 2016

Ability Of The 4-D-Var Analysis Of The Gosat Besd Xco2 Retrievals To Characterize Atmospheric Co2 At Large And Synoptic Scales, Sébastien Massart, Anna Agustí-Panareda, Jens Heymann, Michael Buchwitz, Frédéric Chevallier, Maximilian Reuter, Michael Hilker, J P. Burrows, Nicholas M. Deutscher, D Feist, Frank Hase, Ralf Sussmann, Filip Desmet, Manvendra K. Dubey, David W. T Griffith, Rigel Kivi, Christof Petri, Matthias Schneider, Voltaire A. Velazco

Faculty of Science, Medicine and Health - Papers: part A

This study presents results from the European Centre for Medium-Range Weather Forecasts (ECMWF) carbon dioxide (CO2) analysis system where the atmospheric CO2 is controlled through the assimilation of column-averaged dry-air mole fractions of CO2 (XCO2) from the Greenhouse gases Observing Satellite (GOSAT). The analysis is compared to a free-run simulation (without assimilation of XCO2), and they are both evaluated against XCO2 data from the Total Carbon Column Observing Network (TCCON). We show that the assimilation of the GOSAT XCO2 product from the Bremen Optimal Estimation Differential Optical Absorption Spectroscopy (BESD) algorithm during the year 2013 provides XCO2 fields with an …


Clusterin In The Eye: An Old Dog With New Tricks At The Ocular Surface, M Elizabeth Fini, Aditi Bauskar, Shinwu Jeong, Mark R. Wilson Jan 2016

Clusterin In The Eye: An Old Dog With New Tricks At The Ocular Surface, M Elizabeth Fini, Aditi Bauskar, Shinwu Jeong, Mark R. Wilson

Faculty of Science, Medicine and Health - Papers: part A

The multifunctional protein clusterin (CLU) was first described in 1983 as a secreted glycoprotein present in ram rete testis fluid that enhanced aggregation ('clustering') of a variety of cells in vitro. It was also independently discovered in a number of other systems. By the early 1990s, CLU was known under many names and its expression had been demonstrated throughout the body, including in the eye. Its homeostatic activities in proteostasis, cytoprotection, and anti-inflammation have been well documented, however its roles in health and disease are still not well understood. CLU is prominent at fluid-tissue interfaces, and in 1996 it was …


Elucidating The Chemical Structure Of Native 1-Deoxysphingosine, Regula Steiner, Essa M. Saied, Alaa Othman, Christoph Arenz, Alan T. Maccarone, Berwyck L. J Poad, Stephen J. Blanksby, Arnold Von Eckardstein, Thorsten Hornemann Jan 2016

Elucidating The Chemical Structure Of Native 1-Deoxysphingosine, Regula Steiner, Essa M. Saied, Alaa Othman, Christoph Arenz, Alan T. Maccarone, Berwyck L. J Poad, Stephen J. Blanksby, Arnold Von Eckardstein, Thorsten Hornemann

Faculty of Science, Medicine and Health - Papers: part A

The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and diabetes type 2 and might contribute to β cell failure and the diabetic sensory neuropathy. In analogy to canonical sphingolipids, it was assumed that 1-deoxySLs also bear a (4E) double bond, which is normally introduced by sphingolipid delta(4)-desaturase 1. This, however, was never confirmed. We therefore supplemented HEK293 cells with isotope-labeled D3-1-deoxysphinganine and compared the downstream formed D3-1-deoxysphingosine (1-deoxySO) to a commercial synthetic …


How Humans Adapt To Exercising And Working In The Tropics, Nigel A.S. Taylor Jan 2016

How Humans Adapt To Exercising And Working In The Tropics, Nigel A.S. Taylor

Faculty of Science, Medicine and Health - Papers: part A

Human migration to Australia occurred over 62,000 years ago. Those first Australians established one of the oldest continuous populations on the driest of the inhabited continents, surviving the world's longest drought (>10,000 y). Indeed, the traditional owners established a cultural identity and sustainable lifestyle thousands of years before any of the more recognised ancient civilisations. However, our temperature and rainfall variations belie the national stereotype, with temperatures from -23oC (Charlotte Pass, New South Wales) to 50.7oC (Oodnadatta, South Australia), and annual rainfalls from 125 mm (Lake Eyre, South Australia) through to 12,461 mm in the tropical north-east (Bellenden Ker, …


How To Tackle The Rising Tide Of Poaching In Australia's Tropical Seas, Steven W. Purcell, Hampus B. Eriksson Jan 2016

How To Tackle The Rising Tide Of Poaching In Australia's Tropical Seas, Steven W. Purcell, Hampus B. Eriksson

Faculty of Science, Medicine and Health - Papers: part A

High-value marine species in waters off northern Australia are at increasing risk of poaching by foreign fishing crews, according to figures from the Australian Fisheries Management Authority. The number of foreign fishing boats caught in Australian waters increased from six in 2014-15 to 20 in 2015-16. These fishers have evidently come to poach species that fetch high prices and have been overfished elsewhere in the Asia-Pacific region. They seek "lootable resources" - species that are attractive to the black market because they are expensive, easy to catch and weakly regulated.


Adaptation And Acclimation Of Traits Associated With Swimming Capacity In Lake Whitefish (Coregonus Clupeaformis) Ecotypes, Martin Laporte, Anne C. Dalziel, Nicolas Martin, Louis Bernatchez Jan 2016

Adaptation And Acclimation Of Traits Associated With Swimming Capacity In Lake Whitefish (Coregonus Clupeaformis) Ecotypes, Martin Laporte, Anne C. Dalziel, Nicolas Martin, Louis Bernatchez

Faculty of Science, Medicine and Health - Papers: part A

Background: Improved performance in a given ecological niche can occur through local adaptation, phenotypic plasticity, or a combination of these mechanisms. Evaluating the relative importance of these two mechanisms is needed to better understand the cause of intra specific polymorphism. In this study, we reared populations of Lake Whitefish (Coregonus clupeaformis) representing the 'normal' (benthic form) and the 'dwarf' (derived limnetic form) ecotypes in two different conditions (control and swim-training) to test the relative importance of adaptation and acclimation in the differentiation of traits related to swimming capacity. The dwarf whitefish is a more active swimmer than the normal ecotype, …


Food Security, Food Systems And Food Sovereignty In The 21st Century: A New Paradigm Required To Meet Sustainable Development Goals, Karen E. Charlton Jan 2016

Food Security, Food Systems And Food Sovereignty In The 21st Century: A New Paradigm Required To Meet Sustainable Development Goals, Karen E. Charlton

Faculty of Science, Medicine and Health - Papers: part A

This first issue of the Nutrition & Dietetics for 2016 focuses on food security. As an introduction to the broad spectrum of papers contained therein, this review will consider current definitions of food insecurity and then go on to discuss how to address the determinants of food insecurity (Table 1)4 within a new paradigm defined by the SDGs, as follows: • People (end poverty and hunger); • Planet (ensure sustainability of resources and arrest climate change); • Prosperity (encourage equity and promote technological advancement); and • Peace Partnership (strengthen global solidarity). The review will also consider training and educational needs …


Understanding The Importance Of Collecting Qualitative Data Creatively, Elizabeth J. Halcomb Jan 2016

Understanding The Importance Of Collecting Qualitative Data Creatively, Elizabeth J. Halcomb

Faculty of Science, Medicine and Health - Papers: part A

IN ITS broadest sense, qualitative research encompasses any study that does not use statistical methods or quantify results (Strauss and Corbin 1990). Qualitative researchers undertake their work in the natural setting, attempting to understand or interpret phenomena in terms of the meanings people bring to them.


Indicator-Based Assessment Of Climate-Change Impacts On Coasts: A Review Of Concepts, Methodological Approaches And Vulnerability Indices, Thang T. X Nguyen, Jarbas Bonetti, Kerrylee Rogers, Colin D. Woodroffe Jan 2016

Indicator-Based Assessment Of Climate-Change Impacts On Coasts: A Review Of Concepts, Methodological Approaches And Vulnerability Indices, Thang T. X Nguyen, Jarbas Bonetti, Kerrylee Rogers, Colin D. Woodroffe

Faculty of Science, Medicine and Health - Papers: part A

Increasing human pressures on coastlines and associated threats posed by sea-level rise have stimulated development of a range of different concepts and methodological approaches to assess coastal vulnerability. The first section of this paper summarizes the concepts associated with vulnerability, natural hazards and climate change. The most widely adopted analytical approaches to vulnerability assessment are described, including spatial scales, the need for hybrid approaches comprising both biophysical and social dimensions of vulnerability, and the gradual incorporation of resilience aspects into such methodologies. In particular, the development and application of vulnerability indices is examined, based on a review of more than …


Australians Are Not Meeting The Recommended Intakes For Omega-3 Long Chain Polyunsaturated Fatty Acids: Results Of An Analysis From The 2011-2012 National Nutrition And Physical Activity Survey, Barbara J. Meyer Jan 2016

Australians Are Not Meeting The Recommended Intakes For Omega-3 Long Chain Polyunsaturated Fatty Acids: Results Of An Analysis From The 2011-2012 National Nutrition And Physical Activity Survey, Barbara J. Meyer

Faculty of Science, Medicine and Health - Papers: part A

Health benefits have been attributed to omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). Therefore it is important to know if Australians are currently meeting the recommended intake for n-3 LCPUFA and if they have increased since the last National Nutrition Survey in 1995 (NNS 1995). Dietary intake data was obtained from the recent 2011-2012 National Nutrition and Physical Activity Survey (2011-2012 NNPAS). Linoleic acid (LA) intakes have decreased whilst alpha-linolenic acid (LNA) and n-3 LCPUFA intakes have increased primarily due to n-3 LCPUFA supplements. The median n-3 LCPUFA intakes are less than 50% of the mean n-3 LCPUFA intakes …