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Articles 61 - 64 of 64
Full-Text Articles in Social and Behavioral Sciences
Synthesis Of Spirocyclopente-Dione Anthracene Adduct, Precursor Of The Cyclopentenone Prostagladins Via Ring-Closing Metathesis Reaction, Gedsirin Eksinitkun, Stephen G. Pyne, Waya S. Phutdhawong, Weerachai Phutdhawong
Synthesis Of Spirocyclopente-Dione Anthracene Adduct, Precursor Of The Cyclopentenone Prostagladins Via Ring-Closing Metathesis Reaction, Gedsirin Eksinitkun, Stephen G. Pyne, Waya S. Phutdhawong, Weerachai Phutdhawong
Faculty of Science, Medicine and Health - Papers: part A
A synthesis of the spirocyclopente-dione anthracene adduct, a precursor of the cyclopentenone prostaglandins has been reported. The synthesis involved a Diels-Alder reaction of anthracene and dimethyl fumarate to afford 3 followed by reduction, oxidation and esterification reactions to provide methyl ester anthracene adduct 8, which further converted to the the allylic alcohol (12). Then, Ring-Closing Metathesis (RCM) reaction afforded the cyclopentenol anthracene adduct, which after oxidation provided the spirocyclopente-dione anthracene adduct in good yields.
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Faculty of Science, Medicine and Health - Papers: part A
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission, with implications for the pathophysiology of schizophrenia. Post-mortem studies have demonstrated altered NRG1-ErbB4 signalling in the brain of schizophrenia patients. Antipsychotic drugs have different effects on NRG1-ErbB4 signalling depending on treatment duration. Abnormal behaviours relevant to certain features of schizophrenia are displayed in NRG1/ErbB4 knockout mice or …
Bacterial Filtration Using Carbon Nanotube/Antibiotic Buckypaper Membranes, Luke J. Sweetman, Leighton J. Alcock, Jason D. Mcarthur, Elise M. Stewart, Gerry Triani, Marc In Het Panhuis, Stephen F. Ralph
Bacterial Filtration Using Carbon Nanotube/Antibiotic Buckypaper Membranes, Luke J. Sweetman, Leighton J. Alcock, Jason D. Mcarthur, Elise M. Stewart, Gerry Triani, Marc In Het Panhuis, Stephen F. Ralph
Faculty of Science, Medicine and Health - Papers: part A
The preparation of free-standing carbon nanotube “buckypaper” (BP) membranes consisting of either single-walled carbon nanotubes (SWNTs) or multi-walled carbon nanotubes (MWNTs), and the antibiotic ciprofloxacin (cipro), is reported. The electrical, mechanical and morphological properties of these membranes have been characterised and are compared to those of the corresponding buckypaper membranes containing the surfactant Triton X-100 (Trix). Analysis of scanning electron microscopic images of the surfaces of SWNT/cipro and SWNT/Trix (Trix = Triton X-100) buckypapers revealed that the diameter of their surface pores was significantly smaller than that of the corresponding materials prepared using MWNTs. Similarly, the average internal pore diameter …
Human P2x7 Receptor Activation Induces The Rapid Shedding Of Cxcl16, Aleta Pupovac, Christopher M. Foster, Ronald Sluyter
Human P2x7 Receptor Activation Induces The Rapid Shedding Of Cxcl16, Aleta Pupovac, Christopher M. Foster, Ronald Sluyter
Faculty of Science, Medicine and Health - Papers: part A
Activation of the purinergic P2X7 receptor by extracellular ATP induces the shedding of cell-surface molecules including the low-affinity IgE receptor, CD23 from leukocytes. CD23 is a known substrate of a disintegrin and metalloprotease (ADAM)10. The aim of the current study was to determine if P2X7 activation induced the shedding of the chemokine CXCL16, an ADAM10 substrate. Using immunolabelling and flow cytometry we demonstrate that human RPMI 8226 multiple myeloma B cells, which have been previously shown to express P2X7, also express CXCL16. Flow cytometric and ELISA measurements of ATP-induced loss of cell-surface CXCL16 showed that ATP treatment of RPMI 8226 …