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Full-Text Articles in Social and Behavioral Sciences
The Physiological Effects Of Resistant Starch On Obesity And Diabetes, Felicia Robin Goldsmith
The Physiological Effects Of Resistant Starch On Obesity And Diabetes, Felicia Robin Goldsmith
LSU Doctoral Dissertations
Three studies were performed to determine the effects of RS on body weight and adiposity in HF DIO, diabetic C57BL/6J and GLP-1 receptor KO mice as well as genetically obese ZDF rats. The first study was a dose-response experiment for HM260 (0, 15, or 28 g/100 g diet) against the anti-diabetes drug SG (Januvia®) (0 or 0.4 g/100 g diet) in HF DIO C57BL/6J (n=55) mice injected with STZ in order to assess synergy. The most effective combination was used in the second study, the purpose of which was to determine the mechanistic importance of GLP-1 in GLP-1R KO (n=25) …
A High Fat Diet Attenuates The Fermentation Effects Of Resistant Starches And Fructans, Felicia Robin Goldsmith
A High Fat Diet Attenuates The Fermentation Effects Of Resistant Starches And Fructans, Felicia Robin Goldsmith
LSU Master's Theses
In our previous studies, ingestion of prebiotics in low fat diets resulted in decreased cecal pH from 8 to about 6 and increases in short chain fatty acids indicating robust fermentation. However, in some preliminary studies this effect on fermentation was not seen when rodents were obese and/or fed a high-fat diet. This comprehensive high-fat diet study was conducted to determine which sources and combinations of prebiotics would enhance fermentation despite a high dietary fat content. The effects of prebiotics in a high-fat diet (44% energy) on pH, cecal weights, abdominal fat, and body weight were studied in mature male …
Resistant Starch And Sodium Butyrate Reduce Body Fat In Rodents, Kirk Adam Vidrine
Resistant Starch And Sodium Butyrate Reduce Body Fat In Rodents, Kirk Adam Vidrine
LSU Master's Theses
Introduction: Obesity levels in the United States have significantly increased in the last forty years. Lifestyle and pharmacological treatments have been largely ineffective in treating obesity for most people. Both Resistant Starch (RS) and Dietary Sodium Butyrate (SB) are bioactivties which have shown the ability to decrease body fat levels of rodents without increasing physical activity or decreasing energy intake. Glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) are gut hormones that may be involved in increased energy expenditure at a cellular level with dietary RS and SB. Objective: To discern if SB and RS both work through the increase …
Dietary Resistant Starch Improved Maternal Glycemic Control In Goto-Kakizaki Rat, Li Shen
Dietary Resistant Starch Improved Maternal Glycemic Control In Goto-Kakizaki Rat, Li Shen
LSU Doctoral Dissertations
Treatment for maternal hyperglycemia is limited on account of safety concerns for fetus. Our previous work has shown that inclusion of resistant starch in the diet decreases body fat accumulation in rodents, increases GLP-1 at both the gene expression level and plasma levels, and improves glucose tolerance in STZ-induced diabetic mice. However, studies concerning dietary resistant starch and maternal hyperglycemia are scarce. In this project, we examined the effects of dietary resistant starch in pregnant Goto-Kakizaki (GK) rats to improve glycemic control. Animal experiments were conducted to test the hypotheses. In study 1, the female GK rats were randomly grouped …
Resistant Starch Is Effective In Lowering Body Fat In A Rat Model Of Human Endocrine Obesity, Julina Ann Robert
Resistant Starch Is Effective In Lowering Body Fat In A Rat Model Of Human Endocrine Obesity, Julina Ann Robert
LSU Master's Theses
Two studies were performed to determine the effects of resistant starch (RS) on body weight and fat. A 2x2 factorial design was used in both studies, and results were considered significant when p<0.05 for both studies. The first study examined the effects of RS in a high fat diet (44.8% of energy) on weight, fat, peptide-YY (PYY) levels, and cecal pH in male Sprague-Dawley rats. Rats were fed a low fat energy control diet for one week prior to diet treatment. On week two, rats were blocked by weight and fed one of the following diets for 12 weeks (n=10): low fat, energy control (LFEC); LF resistant starch (LFRS); high fat, energy control (HFEC); or high fat resistant starch (HFRS). RS did not lower weight or fat with either the HF or LF diets. RS consumption resulted in greater full and empty cecal weights, and a lower pH for the LFRS diet. This data indicate fermentation, even though weight and fat loss did not occur. This is contrary to previous reports with RS, which has been shown to decrease body fat compared to controls. The second study examined the effects of RS on the weight, fat, PYY levels, and glucagon-like peptide-1 (GLP-1) levels in female Sprague-Dawley rats. Ovariectomized (OVX) rats were used to represent rats prone to gaining weight, and sham rats represented normal rats. Rats were assigned to one of four groups (n=10): OVEC, OVRS, SHEC, or SHRS. Rats were fed the EC diet for 6 weeks prior to diet treatment to gain weight after surgery, and then blocked by weight and fat into diet treatment groups, and spent 13 weeks on treatment diets. Energy intake, total gastrointestinal weight, large intestine/cecum weight, and small intestine weight were all higher in RS fed rats relative to EC fed rats. Mesenteric, ovarian, perirenal, retroperitoneal, and total fat pads were lower in RS rats relative to EC rats. Although RS was not effective in lowering body weight or body fat in the first study, the data indicates that resistant starch may lower body weight and fat in postmenopausal women.
Activity-Based Anorexia: The Effects Of Resistant Starch, Holly M. Nguyen
Activity-Based Anorexia: The Effects Of Resistant Starch, Holly M. Nguyen
LSU Master's Theses
Anorexia nervosa is the third most common illness among adolescent females. Approximately one half the cases of anorexia nervosa have been suggested to be activity-induced. Various animal studies have been used to study human anorexia, particularly the activity-based anorexia model (ABA). The ABA paradigm consists of diet restriction and liberal access to activity, which ultimately results in a rapid decrease in both body weight and food intake paradoxical to the significant increase in activity. Because resistant starch (RS) has been shown to initiate a lower rise and a steady level of post-prandial blood glucose, it was hypothesized that a diet …