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Modeling Hiv-1-Associated Neurocognitive Disorders And The Therapeutic Effects Of The Phytoestrogen Metabolite S-Equol In The Hiv-1 Transgenic Rat, Landhing Mary Moran

Theses and Dissertations

HIV-1 associated neurocognitive disorders (HAND) continue to afflict individuals with HIV-1 in the combination antiretroviral treatment (cART) era, most notably affecting executive function, as well as preattentive processing. Currently, there is no effective treatment for HAND, with only adjunctive treatment targeting symptomatic relief. There were two hypotheses in this dissertation: 1) that HIV-1 Tg rats will show disruptions in measures of executive function and preattentive processing, as well as neural network alterations in the prefrontal cortex (PFC), a brain region implicated in executive function, and 2) that administration of the phytoestrogen metabolite S-equol will improve performance as measured by executive …