Social and Behavioral Sciences Commons^™

The Cost-Effectiveness Of Combination Treatment Consisting Of Either Cetuximab Or Panitumumab Plus Folfiri Versus Treatment With Bevacizumab Plus Folfiri As First-Line Treatment For Kras Wild-Type Metastatic Colorectal Cancer Patients In Ontario, Emmanuel M.G. Ewara

Electronic Thesis and Dissertation Repository

I conducted a cost-effectiveness analysis of combination cetuximbab or panitumumab plus FOLFIRI as first-line treatment for patients with metastatic colorectal cancer (MCRC) from the perspective of the Ontario healthcare payer. I developed a Markov decision analytical model to simulate the lifetime costs and benefits of each treatment option. The model was parameterized using data collected from administrative databases in the province of Ontario and from published clinical trials. In the base case scenario, treatment consisting of bevacizumab plus FOLFIRI was found to dominate other treatment options. The ICER values were found to be sensitive to the efficacy of first-line treatment, …

“We Should Be Listening To Our Elders”: Evaluation Of Transfer Of Indigenous Knowledge Between Anishinabe Youth And Elders, Kassandra Kulmann

Electronic Thesis and Dissertation Repository

Indigenous knowledge (IK) (knowledge held by Indigenous peoples regarding local environments, ways of life and culture) can potentially improve health and environment conditions. This thesis examines IK transfer between Anishinabe Elders and youth. A knowledge translation intervention was applied to address community concerns regarding decline of IK transfer between Elders and youth.

Youth were hired to participate in a summer school and interview Elders regarding environment and health issues. Qualitative interviews were conducted with youth before and after their internships to evaluate their experiences and IK uptake. The summer school and internships were effective for facilitating IK transfer between Elders …

How Do Parents Use Health Information With The Aid Of A Knowledge Broker When Living With And Caring For Their Young Children With Cerebral Palsy?, Stephanie E. Lagosky

Electronic Thesis and Dissertation Repository

This research aims to understand how parents use health information (such as those developed from the Move & PLAY study) with the aid of a knowledge broker when living with and caring for young children with cerebral palsy. This research was conducted under a qualitative case study methodology and used questionnaires and in-depth interviews to collect data. Findings include the complexity of both parental use of health information and the desire to use a knowledge broker. A provisional model has been created to help describe information use of parents with young children with cerebral palsy. This provisional model is an …

Intimate Partner Violence (Ipv) And The Social Determinants Of Aboriginal Peoples’ Health: A Case Study Of First Nations Women’S Resilience, Resistance, And Renewal, Julie A. George

Electronic Thesis and Dissertation Repository

Worldwide, First Nations women are among the most vulnerable to Intimate Partner Violence (IPV); and yet, their lived experiences of violence are lacking in the literature. Using Photovoice methodology and a community-based, participatory action approach, this project addresses multiple questions pertaining to First Nations mothers’ experiences of IPV, including: What are the health and social consequences of IPV and how do the social determinants of Aboriginal peoples’ health shape the capacities of women survivors to manage and overcome IPV? Drawing on decolonization theory, a social determinants of Aboriginal peoples’ health framework, and aspects of feminist theory, this project was designed …

Enacting Occupation And Identity: Perspectives Of Children And Their Parents, Shanon K. Phelan

Electronic Thesis and Dissertation Repository

Children with disabilities are at risk for limited opportunities to engage in childhood occupations. Occupation is defined broadly as everything people need, want, or are obliged to do, and as understanding how social dimensions shape occupations and opportunities for participation. Emergent literature suggests that identities are shaped by what we do. This research examines how occupation is implicated in the shaping of identities for school-aged children with physical disabilities in light of the socio-cultural dimensions that shape opportunities for children to participate in childhood occupations.

This work is comprised of five integrated manuscripts, in addition to introduction, methodology, and …

Preliminary Economic Evaluation Of Brentuximab Vedotin In Relapsed And Refractory Hodgkin Lymphoma: An "Early Look" Model Based On Phase Ii Results, Vusal Babashov

Electronic Thesis and Dissertation Repository

We conducted a cost-effectiveness analysis of brentuximab vedotin for the treatment of relapsed and refractory Hodgkin Lymphoma (HL) from health care system perspective in Canada. We developed a Markov decision analytical model to simulate lifetime costs and benefits and parameterized the model using brentuximab phase II clinical trial and cd-link data which is a linked datasets of cancer registry with administrative databases of Ontario, Canada. In the base case scenario, brentuximab treatment led to an increase of 0.352 Quality Adjusted Life Years (QALYs) per person and $108,500 per person, which resulted in incremental cost effectiveness ratio (ICER) of $308,532 per …

Self-Presentation And Social Physique Anxiety In Injury Rehabilitation Settings, Molly Driediger

Electronic Thesis and Dissertation Repository

The objective of this dissertation was to provide an initial description of self-presentation in injury rehabilitation (i.e., physiotherapy). To accomplish this, one qualitative and two quantitative studies were conducted. Study 1 determined whether self-presentational concerns were present in this setting. Female (n = 134) and male (n = 54) undergraduate students with a mean age of 20.64 years (SD = 1.99) completed measures of Social Physique Anxiety (SPA; Hart et al., 1989), self-presentational concerns, and preferences for features of the social and physical physiotherapy environment. An examination of the relationships between these variables revealed that self-presentation exists …

Hearts And Minds: Examining The Evolution Of The Egyptian Excerebration And Evisceration Traditions Through The Impact Mummy Database, Andrew D. Wade

Electronic Thesis and Dissertation Repository

Egyptian mummification and funerary rituals were a transformative process, making the deceased a pure being; free of disease, injury, and disfigurements, as well as ethical and moral impurities. Consequently, the features of mummification available to specific categories of individuals hold social and ideological significance. This study refutes long-held classical stereotypes, particularly dogmatic class associations; demonstrates the apocryphal nature of universal heart retention; and expands on the purposes of excerebration and evisceration implied by synthetic and radiological analyses.

Features of the embalming traditions, specifically the variable excerebration and evisceration traditions, represented the Egyptian view of death. Fine-grain analyses, through primary imaging …

Motherhood And Childbirth Experiences Among Newcomer Women In Canada: A Critical Ethnographic Study, Fatmeh Ahmad Alzoubi

Electronic Thesis and Dissertation Repository

Statement of the Problem: Motherhood and childbirth are very sensitive experiences and have a strong impact on family functioning, social identity, and cohesiveness. Although motherhood and childbirth have been discussed extensively in the scholarly and popular literature, much of this work has been conducted from a North American perspective, with little attention to how motherhood and childbirth are experienced by newcomer women from diverse racial and cultural backgrounds.

Methodology and Theoretical Orientation: A critical ethnographic study using in-depth interviews with 16 newcomer women was utilized to explore newcomer women’s experiences and understandings of motherhood and childbirth in the aftermath of …

Development Of A Cohesion Inventory For Children's Sport Teams, Luc J. Martin

Electronic Thesis and Dissertation Repository

The general purpose of this dissertation was to develop an inventory designed to measure cohesion in children’s (ages 9-12) sport teams. To this end, three studies were conducted. In Study 1, children became active agents in the process of test construction. More specifically, children (N = 167) participated in focus groups and completed open-ended questionnaires in order to provide information on their perceptions of cohesion as well as motives for participating, continuing, and ceasing involvement on sport teams. Study 2 involved the use of the information obtained from Study 1 to develop potential items for the questionnaire. In addition, the …

The Importance Of Self-Efficacy And Basic Psychological Needs In Children’S Physical Activity: Measurement, Prediction And Intervention, Casey E. Gray

Electronic Thesis and Dissertation Repository

The importance of physical activity in the overall health promotion and primary prevention of cardiovascular disease risk factors and metabolic diseases in children is well established. Nonetheless, interventions to increase physical activity among this population have been largely unsuccessful. The main objective of the research in this dissertation was to explore the suitability of self-efficacy and basic psychological needs for physical activity prediction and intervention in children. Item generation and psychometric evaluation of psychological questionnaires occurred in study 1 (Chapter 2). Using a prospective design, study 2 (Chapter 3) established task efficacy, barriers efficacy, competence, and autonomy as significant predictors …