Social and Behavioral Sciences Commons^™

Limbic Hyperactivation During Processing Of Neutral Facial Expressions In Children With Bipolar Disorder, Brendan A. Rich, Deborah T. Vinton, Roxann Roberson-Nay, Lisa H. Berghorst, Erin B. Mcclure, Stephen Fromm, Daniel Pine, Ellen Leibenluft

Psychology Faculty Publications

A major paradigm shift in mental health has led to the ascendance of the view that chronic psychopathology results from perturbed neural development. While most work in this area examines schizophrenia, the current report extends the paradigm to bipolar disorder (BD) in youth, thus demonstrating traction (not sure I understand what you mean here) in the developmental-psychobiology perspective. To study the role of amygdala dysfunction, we examined the neural mechanisms mediating face processing in 22 youth (mean age 14.21 + 3.11 years) with BD and 21 controls of comparable age, gender, and IQ. Event-related fMRI compared neural activation when attention …