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Social and Behavioral Sciences Commons™
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- Blood (1)
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- Calliphoridae (1)
- Decomposition ecology (1)
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- Dopamine transporter (1)
- Drug Facilitated Crime (1)
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- Δ-9-tetrahydrocannabinol (1)
Articles 1 - 5 of 5
Full-Text Articles in Social and Behavioral Sciences
Analysis Of Synthetic Opioids In Postmortem Blood, Vitreous Humor, And Brain Tissue, Rachel K. Chesser
Analysis Of Synthetic Opioids In Postmortem Blood, Vitreous Humor, And Brain Tissue, Rachel K. Chesser
Student Theses
In the United States, the use of new synthetic opioids (e.g. fentanyl and derivatives) has become an increasing health issue with thousands of overdose deaths being observed since 2013. With the high mortality rate associated with these substances, postmortem analyses and interpretation of synthetic opioids has become extremely important. However, due to the novelty of these compounds, the available data is limited and provides challenges to toxicologists. The focus of this project was to examine the postmortem distribution of new synthetic opioids in blood, vitreous humor, and brain tissue. New methods were developed and validated to quantify 13 synthetic opioids …
Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth
Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth
Student Theses
A liquid chromatography tandem mass spectrometry (LC-MSMS) method was developed and validated to detect for the presence of zolpidem in human hair samples. Zolpidem is a sedative hypnotic whose adverse effects make it a common drug found in drug facilitated crimes (DFC). It is important to be able to detect and quantitate the drug after a long period of time due to the victim’s delayed reporting of the crime. Hair’s long window of detection makes it a useful matrix for DFC investigations. The linear range of the assay was targeted at 2 pg/mg to 1,000 pg/mg and experiments designed to …
Δ-9-Thc Effect On The Dopamine Transporter, Brooke E. Nielsen
Δ-9-Thc Effect On The Dopamine Transporter, Brooke E. Nielsen
Student Theses
Understanding the mechanism behind drugs of abuse is one of the key elements to understanding why addiction is so prevalent in society. The goal of this research was to determine the effect that a popular cannabinoid, Δ -9-tetrahydrocannabinol has on the regulation of dopamine neurotransmitter in the synapses. It was hypothesized that the addictive high users experience from using Δ-9-THC had a direct effect on lowering the dopamine transporter protein on cell surface causing a buildup of dopamine in the synapse. The results of the study show that the higher concentration of Δ-9-THC that the cells were exposed to caused …
The Y-Screen Assay: Validation And Evaluation Of Subsequent Str Success, Kassandra Luyando
The Y-Screen Assay: Validation And Evaluation Of Subsequent Str Success, Kassandra Luyando
Student Theses
There are hundreds of untested sexual assault kits in police custody. As of 2017, New York State passed a law stating that all untested kits must be turned over to forensic laboratories to be tested, causing backlogs at laboratories to increase. The Y-Screen assay is a DNA extraction protocol which utilizes NaOH to rapidly lyse epithelial and sperm cells, and the Quantifiler Trio DNA quantification kit to detect the presence or absence of male DNA prior to standard sample processing. The Y-Screen assay is a commercial product used in this research to test a defined set of validation samples with …
Ant Predation Of Blow Flies During Decomposition And Its Potential Impact On Pmi Estimations, Vincent J. Nappi
Ant Predation Of Blow Flies During Decomposition And Its Potential Impact On Pmi Estimations, Vincent J. Nappi
Student Theses
When an organism dies, the process of decomposition begins and many insects are attracted to the decomposing remains, or carrion, as a prospective food source for themselves, or their offspring. Blow flies (Family: Calliphoridae), in particular, are one of the first insects to discover and colonize a dead body due to the ability to detect a decomposing resource from large distances. As a result, forensic entomologists take advantage of the behavior and developmental cycles of early colonizers to calculate the post-mortem interval (PMI) in order to determine the time since death. However, along with the insects that are attracted to …