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Social and Behavioral Sciences Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Social and Behavioral Sciences
Par2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis In Mice, Shannon M. Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E. Hall, Lisa M. Mckinney, Nathan Robbins, Joel Thompson, Abigail D. Peairs, Eric Camerer, Katey J. Rayner, Michael Tranter, Nigel Mackman, A. Phillip Owens
Par2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis In Mice, Shannon M. Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E. Hall, Lisa M. Mckinney, Nathan Robbins, Joel Thompson, Abigail D. Peairs, Eric Camerer, Katey J. Rayner, Michael Tranter, Nigel Mackman, A. Phillip Owens
Exercise and Sport Studies: Faculty Publications
Objective-PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis. Approach and Resutle-PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma versus control carotid and aortic arch arteries, respectively. To determine the effect of PAR2 deficiency on atherosclerosis, male and female low-density lipoprotein receptor-deficient (Ldlr-/-) mice (8-12 weeks old) that were Par2+/+ or Par2-/- were fed a fat-and cholesterol-enriched diet for 12 or 24 weeks. …
Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess
Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess
Exercise and Sport Studies: Faculty Publications
Circulating angiogenic cells (CAC) influence vascular repair through the secretion of proangiogenic factors and cytokines. While CAC are deficient in patients with diabetes and exercise has a beneficial effect on CACs, the impact of these factors on paracrine secretion from CAC is unknown. We aimed to determine whether the in vitro secretion of selected cytokines and nitric oxide (NO) from CAC is influenced by hyperglycemia and acute exercise. Colonyforming unit CAC (CFU-CAC) were cultured from young active men (n = 9, 24 ± 2 years) at rest and after exercise under normal (5 mmol/L) and elevated (15 mmol/L) glucose. Preliminary …
Endothelial And Inflammatory Responses To Acute Exercise In Perimenopausal And Late Postmenopausal Women, Corinna Serviente, Lisa M. Troy, Maxine De Jonge, Daniel D. Shill, Nathan T. Jenkins, Sarah Witkowski
Endothelial And Inflammatory Responses To Acute Exercise In Perimenopausal And Late Postmenopausal Women, Corinna Serviente, Lisa M. Troy, Maxine De Jonge, Daniel D. Shill, Nathan T. Jenkins, Sarah Witkowski
Exercise and Sport Studies: Faculty Publications
Endothelial dysfunction and inflammation are characteristics of subclinical atherosclerosis and may increase through progressive menopausal stages. Evaluating endothelial responses to acute exercise can reveal underlying dysfunction not apparent in resting conditions. The purpose of this study was to investigate markers of endothelial function and inflammation before and after acute exercise in healthy low-active perimenopausal (PERI) and late postmenopausal (POST) women. Flow-mediated dilation (FMD), CD31+/CD42b- and CD62E+ endothelial microparticles (EMPs), and the circulating inflammatory factors monocyte chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8), and tumor necrosis factor-α (TNF-α) were measured before and 30 min after acute exercise. Before exercise, FMD was …