Social and Behavioral Sciences Commons^™

The Influence Of Habitual Physical Activity And Sedentary Behavior On Objective And Subjective Hot Flashes At Midlife, Sarah Witkowski, Quinn White, Sofiya Shreyer, Daniel E. Brown, Lynette Leidy Sievert

Exercise and Sport Studies: Faculty Publications

The years surrounding the transition to menopause are marked by multiple challenges to health. Hot flashes are a commonly reported symptom of women at this time and their frequency has been associated with disease risk. Regular physical activity and reduced sedentary time are recommended for health and wellbeing. However, the effect of physical activity and sedentary behavior on hot flashes remains unclear. OBJECTIVE: The purpose of this study was to evaluate relationships between physical activity, sedentary time and hot flashes during both waking and sleeping periods using concurrent objective and subjective measures of hot flashes in midlife women. METHODS: Women …

Acute Increases In Physical Activity And Temperature Are Associated With Hot Flash Experience In Midlife Women, Sarah Witkowski, Quinn White, Sofiya Shreyer, Randi L. Garcia, Daniel E. Brown, Lynnette Leidy Sievert

Exercise and Sport Studies: Faculty Publications

Objective: This study determined the association between acute changes in physical activity, temperature and humidity and 24-hour subjective and objective hot flash experience.

Methods: Data collection occurred during the cooler months of the year in Western Massachusetts (October-April). Women aged 45-55 across 3 menopause stages (n=270) were instrumented with ambulatory monitors to continuously measure hot flashes, physical activity, temperature and humidity for 24-hours. Objective hot flashes were assessed via sternal skin conductance, and subjective hot flashes were recorded by pressing an event marker and data logging. Physical activity was measured with wrist-worn accelerometers and used to define sleep and wake …

Trauma Prevalence And Desire For Trauma-Informed Coaching In Collegiate Sports: A Mixed Methods Study, Elizabeth Alma Hertzler-Mccain, Aerin Mcquillen, Shalini Setty, Stephanie Lopez, Erica Tibbetts

Exercise and Sport Studies: Faculty Publications

This study investigated trauma prevalence amongst collegiate student-athletes and openness towards trauma-informed coaching practices among athletes and coaches at two small Division III colleges. Surveys gathered quantitative data from athletes (n = 91) and coaches (n =18) and qualitative data from athletes (n = 33). Quantitative results indicated that 52.7% of athletes experienced at least one potentially traumatic event during their lifetime. The most prevalent trauma was unwanted sexual contact. Additionally, 50.5% of athletes experienced sport-based harassment or abuse during their lifetime, with 21.7% of affected athletes experiencing said abuse in college sports. Athletes reported that 8 out of 10 …

Physical Activity And Exercise For Hot Flashes: Trigger Or Treatment?, Sarah Witkowski, Rose Evard, Jacquelyn J. Rickson, Quinn White, Lynnette Leidy Sievert

Exercise and Sport Studies: Faculty Publications

Importance and Objective: Hot flashes (HFs) are a prevalent feature of menopause. Hot flashes can be bothersome and affect quality of life. However, HFs have also been associated with the risk for cardiovascular disease. Therefore, providing current evidence on the effect of therapies to reduce HFs can help patients and providers with decision making. This review provides details on the scientific evidence to date related to the effect of physical activity (PA) and exercise to alter the HF experience in women

Methods: The PubMed database was searched between June 2020 and June 2022 for currently available evidence regarding the relation …

A Comparison Of Stress, Symptoms, Physical Activity, And Adiposity Among Women At Midlife Before And During The Pandemic, Lynnette Leldy Stevert, Sofiya Shreyer, Ashley Boudreau, Sarah Witkowski, Daniel E. Brown

Exercise and Sport Studies: Faculty Publications

Background: The COVID-19 pandemic presented challenges that disproportionately impacted women. Household roles typically performed by women (such as resource acquisition and caretaking) became more difficult due to financial strain, fear of infection, and limited childcare options among other concerns. This research draws from an ongoing study of hot flashes and brown adipose tissue to examine the health-related effects of the COVID-19 pandemic among 162 women aged 45–55 living in western Massachusetts.

Methods: We compared women who participated in the study pre- and early pandemic with women who participated mid-pandemic and later-pandemic (when vaccines became widely available). We collected self-reported symptom …

Dual Goals Of Trunk Restriction And Stability Are Prioritized By Individuals With Chronic Low Back Pain During A Volitional Movement, Stephanie L. Jones, Juvena R. Hitt, Sharon M. Henry

Exercise and Sport Studies: Faculty Publications

Background

Individuals with chronic low back pain demonstrate impaired responses to volitional and externally-generated postural perturbations that may impact stability whilst performing activities of daily living. Understanding how balance may be impaired by strategy selection is an important consideration during rehabilitation from low back pain to prevent future injurious balance loss.

Research question

This cross-sectional study explored the influence of an active pain episode on volitional movement patterns and stability during a sit-to-stand task in individuals with chronic low back pain compared to those with no low back pain history.

Methods

Thirteen participants with low back pain who were in …

Sensorimotor Function In Progressive Multiple Sclerosis, Jules D. Miehm, John Buonaccorsi, Jongil Lim, Sumire Sato, Caitlin Rajala, Julianna Averill, Farnaz Khalighinejad, Carolina Ionete, Stephanie L. Jones, Jane A. Kent, Richard E.A. Van Emmerik

Exercise and Sport Studies: Faculty Publications

Background: A sensitive test reflecting subtle sensorimotor changes throughout disease progression independent of mobility impairment is currently lacking in progressive multiple sclerosis.

Objectives: We examined non-ambulatory measures of upper and lower extremity sensorimotor function that may reveal differences between relapsing–remitting and progressive forms of multiple sclerosis.

Methods: Cutaneous sensitivity, proprioception, central motor function and mobility were assessed in 32 relapsing–remitting and 31 progressive multiple sclerosis patients and 30 non-multiple sclerosis controls.

Results: Cutaneous sensation differed between relapsing–remitting and progressive multiple sclerosis at the foot and to a lesser extent the hand. Proprioception function in the upper but not the lower …

Follicle-Stimulating Hormone, But Not Cardiorespiratory Fitness, Is Associated With Flow-Mediated Dilation With Advancing Menopausal Stage, Corinna Serviente, Sarah Witkowski

Exercise and Sport Studies: Faculty Publications

Objective:The aim of the study was to evaluate if there are differences in endothelial function before and after acute exercise in women at different menopausal stages with high and low cardiorespiratory fitness.Methods:Participants were healthy high-fit premenopausal (n = 11), perimenopausal (n = 12), and postmenopausal women (n = 13) and low-fit perimenopausal (n = 7) and postmenopausal women (n = 8). Brachial artery flow-mediated dilation (FMD) was measured before and after acute moderate intensity exercise. FMD was calculated as (Diameterpeak-Diameterbaseline)/ Diameterbaseline) × 100. Differences between high-fit women and between high- and low-fit perimenopausal and postmenopausal women were assessed with repeated-measure …

Follicle-Stimulating Hormone Is Associated With Lipids In Postmenopausal Women, Corinna Serviente, Tomi-Pekka Tuomainen, Jyrki Virtanen, Sarah Witkowski, Leo Niskanen, Elizabeth Bertone-Johnson

Exercise and Sport Studies: Faculty Publications

Objective: The purpose of this study was to evaluate the relation between FSH and lipid levels in postmenopausal women from the Kuopio Ischaemic Heart Disease Risk Factor Study.

Methods: Postmenopausal women (n = 588) aged 53 to 73 years and not using hormone therapy were included. The relation between FSH and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) was evaluated using linear regression, adjusting for estradiol, body mass, smoking, and other hormonal and lifestyle factors. The relation between FSH, dyslipidemia, and abnormal lipid levels were also evaluated.

Results: FSH was positively and linearly …

Type 2 Diabetes Impairs The Ability Of Skeletal Muscle Pericytes To Augment Postischemic Neovascularization In Db/Db Mice, Katherine L. Hayes, Louis M. Messina, Lawrence M. Schwartz, Jinglian Yan, Amy S. Burnside, Sarah Witkowski

Exercise and Sport Studies: Faculty Publications

Peripheral artery disease is an atherosclerotic occlusive disease that causes limb ischemia and has few effective noninterventional treatments. Stem cell therapy is promising, but concomitant diabetes may limit its effectiveness. We evaluated the therapeutic potential of skeletal muscle pericytes to augment postischemic neovascularization in wild-type and type 2 diabetic (T2DM) mice. Wild-type C57BL/6J and leptin receptor spontaneous mutation db/db T2DM mice underwent unilateral femoral artery excision to induce limb ischemia. Twenty-four hours after ischemia induction, CD45-CD34-CD146+ skeletal muscle pericytes or vehicle controls were transplanted into ischemic hindlimb muscles. At postoperative day 28, pericyte transplantation augmented blood flow recovery in wild-type …

Post-Fatigue Recovery Of Power, Postural Control And Physical Function In Older Women, Stephen A. Foulis, Stephanie L. Jones, Richard E. Van Emmerik, Jane A. Kent

Exercise and Sport Studies: Faculty Publications

Low muscle power, particularly at high velocities, has been linked to poor physical function in older adults. Any loss in muscle power following fatiguing exercise or daily activities could impact physical function and postural control until power has fully recovered. To test the overall hypothesis that a common task such as walking can result in prolonged power loss and decreased physical function and balance, 17 healthy older (66–81 years) women completed a 32-min walking test (32MWT) designed to induce neuromuscular fatigue, followed by 60min of recovery (60R). Fatigue and recovery of knee extensor muscle power (3 velocities) were quantified by …

Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess

Exercise and Sport Studies: Faculty Publications

Circulating angiogenic cells (CAC) influence vascular repair through the secretion of proangiogenic factors and cytokines. While CAC are deficient in patients with diabetes and exercise has a beneficial effect on CACs, the impact of these factors on paracrine secretion from CAC is unknown. We aimed to determine whether the in vitro secretion of selected cytokines and nitric oxide (NO) from CAC is influenced by hyperglycemia and acute exercise. Colonyforming unit CAC (CFU-CAC) were cultured from young active men (n = 9, 24 ± 2 years) at rest and after exercise under normal (5 mmol/L) and elevated (15 mmol/L) glucose. Preliminary …

Endothelial And Inflammatory Responses To Acute Exercise In Perimenopausal And Late Postmenopausal Women, Corinna Serviente, Lisa M. Troy, Maxine De Jonge, Daniel D. Shill, Nathan T. Jenkins, Sarah Witkowski

Exercise and Sport Studies: Faculty Publications

Endothelial dysfunction and inflammation are characteristics of subclinical atherosclerosis and may increase through progressive menopausal stages. Evaluating endothelial responses to acute exercise can reveal underlying dysfunction not apparent in resting conditions. The purpose of this study was to investigate markers of endothelial function and inflammation before and after acute exercise in healthy low-active perimenopausal (PERI) and late postmenopausal (POST) women. Flow-mediated dilation (FMD), CD31+/CD42b- and CD62E+ endothelial microparticles (EMPs), and the circulating inflammatory factors monocyte chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8), and tumor necrosis factor-α (TNF-α) were measured before and 30 min after acute exercise. Before exercise, FMD was …

Pericyte Nf-Κb Activation Enhances Endothelial Cell Proliferation And Proangiogenic Cytokine Secretion In Vitro, Katherine E. Labarbera, Robert D. Hyldahl, Kevin S. O'Fallon, Priscilla M. Clarkson, Sarah Witkowski

Exercise and Sport Studies: Faculty Publications

Pericytes are skeletal muscle resident, multipotent stem cells that are localized to the microvasculature. In vivo, studies have shown that they respond to damage through activation of nuclear-factor kappa-B (NF-κB), but the downstream effects of NF-κB activation on endothelial cell proliferation and cell– cell signaling during repair remain unknown. The purpose of this study was to examine pericyte NF-κB activation in a model of skeletal muscle damage; and use genetic manipulation to study the effects of changes in pericyte NF-κB activation on endothelial cell proliferation and cytokine secretion. We utilized scratch injury to C2C12 cells in coculture with human primary …

Circulating Angiogenic Cell Population Responses To 10 Days Of Reduced Physical Activity, Gayatri Guhanarayan, Julianne Jablonski, Sarah Witkowski

Exercise and Sport Studies: Faculty Publications

Circulating angiogenic cells (CACs) are a diverse group that have been identified as predictors of cardiovascular health and are inversely proportional to cardiovascular disease (CVD) outcomes. Inactivity is a growing concern in industrialized nations and is an independent risk factor for CVD. There is limited evidence regarding the impact of reduced physical activity (rPA) on different CAC populations. The purpose of this study was to evaluate the effect of objectively monitored rPA with maintained energy balance on two CAC populations (CFU and CD34+cells), intracellular nitric oxide (NOi), and genes related to NO production in active, healthy men. Participants (age 25 …

Defining The "Dose" Of Altitude Training: How High To Live For Optimal Sea Level Performance Enhancement, Robert F. Chapman, Trine Karlsen, Geir K. Resaland, R. L. Ge, Matthew P. Harber, Sarah Witkowski, James Stray-Gundersen, Benjamin D. Levine

Exercise and Sport Studies: Faculty Publications

Defining the "dose" of altitude training: how high to live for optimal sea level performance enhancement. J Appl Physiol 116: 595-603, 2014. First published October 24, 2013; doi:10.1152/japplphysiol.00634.2013.-Chronic living at altitudes of 2,500 m causes consistent hematological acclimatization in most, but not all, groups of athletes; however, responses of erythropoietin (EPO) and red cell mass to a given altitude show substantial individual variability. We hypothesized that athletes living at higher altitudes would experience greater improvements in sea level performance, secondary to greater hematological acclimatization, compared with athletes living at lower altitudes. After 4 wk of group sea level training and …

Sex-Specific Effects Of Exercise Ancestry On Metabolic, Morphological And Gene Expression Phenotypes In Multiple Generations Of Mouse Offspring, Lisa M. Guth, Andrew T. Ludlow, Sarah Witkowski, Mallory R. Marshall, Laila C.J. Lima, Andrew C. Venezia, Tao Xiao, Mei Ling Ting Lee, Espen E. Spangenburg, Stephen M. Roth

Exercise and Sport Studies: Faculty Publications

New findings: • What is the central question of this study? How does parental exercise training directly and/or transgenerationally affect offspring phenotypes over two generations of mice? • What is the main finding and what is its importance? We observed preliminary evidence that parental exercise training can influence health-related phenotypes (e.g. body and fat mass, muscle gene expression) in mouse offspring. These findings indicate that parental exercise may be another environmental factor (like altered nutrition) capable of influencing offspring phenotypes in adulthood. Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting …

Chronic Exercise Modifies Age-Related Telomere Dynamics In A Tissue-Specific Fashion, Andrew T. Ludlow, Sarah Witkowski, Mallory R. Marshall, Jenny Wang, Laila C.J. Lima, Lisa M. Guth, Espen E. Spangenburg, Stephen M. Roth

Exercise and Sport Studies: Faculty Publications

We evaluated the impact of long-term exercise on telomere dynamics in wild-derived short telomere mice (CAST/Ei) over 1 year. We observed significant telomere shortening in liver and cardiac tissues in sedentary 1-year-old mice compared with young (8 weeks) baseline mice that were attenuated in exercised 1-year-old animals. In contrast, skeletal muscle exhibited significant telomere shortening in exercise mice compared with sedentary and young mice. Telomerase enzyme activity was increased in skeletal muscle of exercise compared with sedentary animals but was similar in cardiac and liver tissues. We observed significant age-related decreases in expression of telomere-related genes that were attenuated by …

Individuals With Non-Specific Low Back Pain In An Active Episode Demonstrate Temporally Altered Torque Responses And Direction-Specific Enhanced Muscle Activity Following Unexpected Balance Perturbations, Stephanie L. Jones, Juvena R. Hitt, Michael J. Desarno, Sharon M. Henry

Exercise and Sport Studies: Faculty Publications

Individuals with a history of non-specific low back pain (LBP) while in a quiescent pain period demonstrate altered automatic postural responses (APRs) characterized by reduced trunk torque contributions and increased co-activation of trunk musculature. However, it is unknown whether these changes preceded or resulted from pain. To further delineate the relationship between cyclic pain recurrence and APRs, we quantified postural responses following multi-directional support surface translations, in individuals with non-specific LBP, following an active pain episode. Sixteen subjects with and 16 without LBP stood on two force plates that were translated unexpectedly in 12 directions. Net joint torques of the …

Individuals With Non-Specific Low Back Pain Use A Trunk Stiffening Strategy To Maintain Upright Posture, Stephanie L. Jones, Sharon M. Henry, Christine C. Raasch, Juvena R. Hitt, Janice Y. Bunn

Exercise and Sport Studies: Faculty Publications

There is increasing evidence that individuals with non-specific low back pain (LBP) have altered movement coordination. However, the relationship of this neuromotor impairment to recurrent pain episodes is unknown. To assess coordination while minimizing the confounding influences of pain we characterized automatic postural responses to multi-directional support surface translations in individuals with a history of LBP who were not in an active episode of their pain. Twenty subjects with and 21 subjects without non-specific LBP stood on a platform that was translated unexpectedly in 12 directions. Net joint torques of the ankles, knees, hips, and trunk in the frontal and …

A History Of Low Back Pain Associates With Altered Electromyographic Activation Patterns In Response To Perturbations Of Standing Balance, Jesse V. Jacobs, Sharon M. Henry, Stephanie L. Jones, Juvena R. Hitt, Janice Y. Bunn

Exercise and Sport Studies: Faculty Publications

People with a history of low back pain (LBP) exhibit altered responses to postural perturbations, and the central neural control underlying these changes in postural responses remains unclear. To characterize more thoroughly the change in muscle activation patterns of people with LBP in response to a perturbation of standing balance, and to gain insight into the influence of early- vs. late-phase postural responses (differentiated by estimates of voluntary reaction times), this study evaluated the intermuscular patterns of electromyographic (EMG) activations from 24 people with and 21 people without a history of chronic, recurrent LBP in response to 12 directions of …

Plasma Fetuin-A Concentrations In Young And Older High- And Low-Active Men, Nathan T. Jenkins, Jennifer A. Mckenzie, James M. Hagberg, Sarah Witkowski

Exercise and Sport Studies: Faculty Publications

Fetuin-A is a liver-derived factor that may play a role in insulin resistance and age-related chronic diseases (eg, type 2 diabetes mellitus and cardiovascular [CV] disease). Regular exercise improves CV risk and insulin sensitivity; however, it is unknown whether chronic exercise training is related to circulating levels of fetuin-A. Therefore, this study examined whether plasma fetuin-A levels were related to age and chronic physical activity in men. We hypothesized that chronic physical activity would be related to lower plasma fetuin-A levels in younger and older men. In healthy high-active (HI) and low-active (LO) young (HI, n = 7; LO, n …

Akt1 G205t Genotype Influences Obesity-Related Metabolic Phenotypes And Their Responses To Aerobic Exercise Training In Older Caucasians, Jennifer A. Mckenzie, Sarah Witkowski, Andrew T. Ludlow, Stephen M. Roth, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

As part of the insulin signalling pathway, Akt influences growth and metabolism. The AKT1 gene G205T (rs1130214) polymorphism has potential functional effects. Thus, we determined whether the G205T polymorphism influences metabolic variables and their responses to aerobic exercise training. Following dietary stabilization, healthy, sedentary, 50- to 75-year-old Caucasian men (n= 51) and women (n= 58) underwent 6 months of aerobic exercise training. Before and after completing the intervention, dual-energy X-ray absorptiometry was used to measure percentage body fat, computed tomography to measure visceral and subcutaneous fat, and oral glucose tolerance testing to measure glucose total area under the curve (AUC), …

High-Frequency Electrically Stimulated Skeletal Muscle Contractions Increase P70S6k Phosphorylation Independent Of Known Igf-I Sensitive Signaling Pathways, Sarah Witkowski, Richard M. Lovering, Espen E. Spangenburg

Exercise and Sport Studies: Faculty Publications

Insulin-like growth factor (IGF-I) is hypothesized to be a critical upstream regulator of mammalian target of rapamycin (mTOR)-regulated protein synthesis with muscle contraction. We utilized a mouse model that expresses a skeletal muscle specific dominant-negative IGF-I receptor to investigate the role of IGF-I signaling of protein synthesis in response to unilateral lengthening contractions (10 sets, 6 repetitions, 100. Hz) at 0 and 3. h following the stimulus. Our results indicate that one session of high frequency muscle contractions can activate mTOR signaling independent of signaling components directly downstream of the receptor.

Thrombin And Exercise Similarly Influence Expression Of Cell Cycle Genes In Cultured Putative Endothelial Progenitor Cells, Michael M. Lockard, Sarah Witkowski, Nathan T. Jenkins, Espen E. Spangenburg, Thomas O. Obisesan, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

Acute exercise and exercise training may influence putative endothelial progenitor cell (EPC) number and colony forming units (CFU-ECs), although the mechanisms remain unclear. This study examined the effects of in vitro thrombin supplementation and acute exercise on CFU-EC gene expression, associated with cellular proliferation and differentiation. The effect of habitual physical activity was evaluated through analysis of EPCs from chronically high- and low-active men. Participants were healthy high- and low-active men (n = 23), aged 55-80 yr. Circulating CD34+/VEGFR2+ number, CFU-ECs, plasma prothrombin fragment (F1+2), and thrombin-antithrombin III were measured at rest and after 30 min of exercise. Gene expression …

Endurance Exercise Training Effects On Body Fatness, Vo2max Hdl-C Subfractions, And Glucose Tolerance Are Influenced By A Plin Haplotype In Older Caucasians, Nathan T. Jenkins, Jennifer A. Mckenzie, Coleen M. Damcott, Sarah Witkowski, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

Perilipins are lipid droplet-coating proteins that regulate intracellular lipolysis in adipocytes. A haplotype of two perilipin gene (PLIN) single nucleotide polymorphisms, 13041A>G and 14995A>>T, has been previously associated with obesity risk. Furthermore, the available data indicate that this association may be modified by sex. We hypothesized that this haplotype would associate with body fatness, aerobic fitness, and a number of cardiovascular (CV) risk factor phenotypes before and after a 6-mo endurance exercise training program in sedentary older Caucasians. The major haplotype group (13041A/14995A; n = 57) had significantly lower body mass index (BMI) and body fatness compared with …

Relationship Between Circulating Progenitor Cells, Vascular Function And Oxidative Stress With Long-Term Training And Short-Term Detraining In Older Men, Sarah Witkowski, Michael M. Lockard, Nathan T. Jenkins, Thomas O. Obisesan, Espen E. Spangenburg, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

Exercise may contribute to the maintenance of vascular function via enhanced liberation and action of bone-marrow-derived progenitor cells. Activity related changes in oxidative stress may also influence the number and function of these cells. In the present study, we sought to determine (i) whether adaptations in reactive hyperaemic FBF (forearm blood flow) response associated with long-term endurance exercise and short-term detraining were related to resting putative progenitor cell number and function, and (ii) whether oxidative stress affected these factors. Participants included men with a history of more than 30 years of moderate-to-high-intensity exercise (HI group) and healthy low-active age- and …

Effects Of Acute And Chronic Endurance Exercise On Intracellular Nitric Oxide In Putative Endothelial Progenitor Cells: Role Of Napdh Oxidase, Nathan T. Jenkins, Sarah Witkowski, Espen E. Spangenburg, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

We sought to delineate the effects of acute and chronic exercise on the regulation of intracellular nitric oxide (NOi) production in putative endothelial progenitor cells (EPCs). Putative EPC colony-forming units (CFUEC) were cultured from blood drawn before and after 30 min of treadmill exercise at 75% of maximal oxygen uptake in active (n = 8) and inactive (n = 8) men. CFU-EC were similar between groups at baseline, but increased after exercise in active men only (P = 0.04). CFU-EC expressed lower NADPH oxidase subunit gp91 phox mRNA and elevated endothelial nitric oxide synthase mRNA in active relative to inactive …

Exercise, Apoe, And Working Memory: Meg And Behavioral Evidence For Benefit Of Exercise In Epsilon4 Carriers, Sean P. Deeny, David Poeppel, Jo B. Zimmerman, Stephen M. Roth, Josef Brandauer, Sarah Witkowski, Joseph W. Hearn, Andrew T. Ludlow, José L. Contreras-Vidal, Jason Brandt, Bradley D. Hatfield

Exercise and Sport Studies: Faculty Publications

Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE ε4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in ε4 carriers, but not in the non-carriers after controlling for age, gender, and education (N = 54). Furthermore, the MEG analysis revealed that sedentary ε4 carriers exhibited lower right temporal …

Relationship Between Physical Activity Level, Telomere Length, And Telomerase Activity, Andrew T. Ludlow, Jo B. Zimmerman, Sarah Witkowski, Joe W. Hearn, Bradley D. Hatfield, Stephen M. Roth

Exercise and Sport Studies: Faculty Publications

The purpose of this study was to examine the relationship of exercise energy expenditure (EEE) with both telomere length and telomerase activity in addition to accounting for hTERT C-1327T promoter genotype.