Statistics and Probability Commons^™

Longitudinal Data Methods For Evaluating Genome-By-Epigenome Interactions In Families, Justin C. Strickland, I-Chen Chen, Chanung Wang, David W. Fardo

Psychology Faculty Publications

Background: Longitudinal measurement is commonly employed in health research and provides numerous benefits for understanding disease and trait progression over time. More broadly, it allows for proper treatment of correlated responses within clusters. We evaluated 3 methods for analyzing genome-by-epigenome interactions with longitudinal outcomes from family data.

Results: Linear mixed-effect models, generalized estimating equations, and quadratic inference functions were used to test a pharmacoepigenetic effect in 200 simulated posttreatment replicates. Adjustment for baseline outcome provided greater power and more accurate control of Type I error rates than computation of a pre-to-post change score.

Conclusions: Comparison of all modeling approaches indicated …

Sample Size For Non-Inferiority Tests For One Proportion: A Simulation Study, Özlem Güllü, Mustafa Agah Tekindal

Journal of Modern Applied Statistical Methods

The objective of non-inferiority trials is to demonstrate the efficiency of a novel treatment whether it is acceptably less or more efficient than a control or active (existing) treatment. They are employed in situations where, when compared to the active treatment, the novel treatment is to be advantageous with higher rates of reliability, compatibility, cost-efficiency, etc. Odds ratio is the most significant measure used in investigating the size of efficiency of treatments relative to one another. The purpose of the study is to calculate and evaluate the sample size under different scenarios based on three different test statistics in non-inferiority …