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Full-Text Articles in Statistics and Probability

Nonparametric Population Average Models: Deriving The Form Of Approximate Population Average Models Estimated Using Generalized Estimating Equations, Alan E. Hubbard, Mark J. Van Der Laan Jun 2009

Nonparametric Population Average Models: Deriving The Form Of Approximate Population Average Models Estimated Using Generalized Estimating Equations, Alan E. Hubbard, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

For estimating regressions for repeated measures outcome data, a popular choice is the population average models estimated by generalized estimating equations (GEE). We review in this report the derivation of the robust inference (sandwich-type estimator of the standard error). In addition, we present formally how the approximation of a misspecified working population average model relates to the true model and in turn how to interpret the results of such a misspecified model.


Resampling-Based Multiple Hypothesis Testing With Applications To Genomics: New Developments In The R/Bioconductor Package Multtest, Houston N. Gilbert, Katherine S. Pollard, Mark J. Van Der Laan, Sandrine Dudoit Apr 2009

Resampling-Based Multiple Hypothesis Testing With Applications To Genomics: New Developments In The R/Bioconductor Package Multtest, Houston N. Gilbert, Katherine S. Pollard, Mark J. Van Der Laan, Sandrine Dudoit

U.C. Berkeley Division of Biostatistics Working Paper Series

The multtest package is a standard Bioconductor package containing a suite of functions useful for executing, summarizing, and displaying the results from a wide variety of multiple testing procedures (MTPs). In addition to many popular MTPs, the central methodological focus of the multtest package is the implementation of powerful joint multiple testing procedures. Joint MTPs are able to account for the dependencies between test statistics by effectively making use of (estimates of) the test statistics joint null distribution. To this end, two additional bootstrap-based estimates of the test statistics joint null distribution have been developed for use in the …