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Power And Sample Size Calculations For Interval-Censored Survival Analysis, Hae-Young Kim, John M. Williamson, Hung-Mo Lin
Power And Sample Size Calculations For Interval-Censored Survival Analysis, Hae-Young Kim, John M. Williamson, Hung-Mo Lin
NYMC Faculty Publications
We propose a method for calculating power and sample size for studies involving interval-censored failure time data that only involves standard software required for fitting the appropriate parametric survival model. We use the framework of a longitudinal study where patients are assessed periodically for a response and the only resultant information available to the investigators is the failure window: the time between the last negative and first positive test results. The survival model is fit to an expanded data set using easily computed weights. We illustrate with a Weibull survival model and a two-group comparison. The investigator can specify a …