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Adaptive Randomized Trial Designs That Cannot Be Dominated By Any Standard Design At The Same Total Sample Size, Michael Rosenblum
Adaptive Randomized Trial Designs That Cannot Be Dominated By Any Standard Design At The Same Total Sample Size, Michael Rosenblum
Johns Hopkins University, Dept. of Biostatistics Working Papers
Prior work has shown that certain types of adaptive designs can always be dominated by a suitably chosen, standard, group sequential design. This applies to adaptive designs with rules for modifying the total sample size. A natural question is whether analogous results hold for other types of adaptive designs. We focus on adaptive enrichment designs, which involve preplanned rules for modifying enrollment criteria based on accrued data in a randomized trial. Such designs often involve multiple hypotheses, e.g., one for the total population and one for a predefined subpopulation, such as those with high disease severity at baseline. We fix …