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Full-Text Articles in Statistics and Probability
Optimizing Tumor Xenograft Experiments Using Bayesian Linear And Nonlinear Mixed Modelling And Reinforcement Learning, Mary Lena Bleile
Optimizing Tumor Xenograft Experiments Using Bayesian Linear And Nonlinear Mixed Modelling And Reinforcement Learning, Mary Lena Bleile
Statistical Science Theses and Dissertations
Tumor xenograft experiments are a popular tool of cancer biology research. In a typical such experiment, one implants a set of animals with an aliquot of the human tumor of interest, applies various treatments of interest, and observes the subsequent response. Efficient analysis of the data from these experiments is therefore of utmost importance. This dissertation proposes three methods for optimizing cancer treatment and data analysis in the tumor xenograft context. The first of these is applicable to tumor xenograft experiments in general, and the second two seek to optimize the combination of radiotherapy with immunotherapy in the tumor xenograft …
Influence Diagnostics For Generalized Estimating Equations Applied To Correlated Categorical Data, Louis Vazquez
Influence Diagnostics For Generalized Estimating Equations Applied To Correlated Categorical Data, Louis Vazquez
Statistical Science Theses and Dissertations
Influence diagnostics in regression analysis allow analysts to identify observations that have a strong influence on model fitted probabilities and parameter estimates. The most common influence diagnostics, such as Cook’s Distance for linear regression, are based on a deletion approach where the results of a model with and without observations of interest are compared. Here, deletion-based influence diagnostics are proposed for generalized estimating equations (GEE) for correlated, or clustered, nominal multinomial responses. The proposed influence diagnostics focus on GEEs with the baseline-category logit link function and a local odds ratio parameterization of the association structure. Formulas for both observation- and …