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Controlling The Hydrophilicity And Cohesion During Deposition Of Highly Oriented Type I Collagen Films: An Approach For Biomedical Applications, Karina Ambrock, Bernd Grohe, Silvia Mittler

Physics and Astronomy Publications

Using the Langmuir-Blodgett (LB) technology we have pioneered a straightforward and low-cost approach to fabricate highly oriented collagen in thin film format (thickness: ~20 nm, surface areas: 2.5 x ~6.0 cm). An important factor for the use of these films is their cohesion under various conditions. Film formation was studied by coating hydrophilic or hydrophobic glass substrates. The fresh or aged (2 ½ years, -18°C.) collagen solutions used for this purpose either contained collagen network-stabilizing agents (n-propanol or phosphate ions) or were prepared without these stabilizers. Film formation on the air/water interface was analyzed by pressure-area isotherms. Maximum surface pressures …