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Full-Text Articles in Physics
Sn Vacancies In Photorefractive Sn2P2S6 Crystals: An Electron Paramagnetic Resonance Study Of An Optically Active Hole Trap, Eric M. Golden, Sergey A. Basun, D. R. Evans, A. A. Grabar, I. M. Stoika, Nancy C. Giles, Larry E. Halliburton
Sn Vacancies In Photorefractive Sn2P2S6 Crystals: An Electron Paramagnetic Resonance Study Of An Optically Active Hole Trap, Eric M. Golden, Sergey A. Basun, D. R. Evans, A. A. Grabar, I. M. Stoika, Nancy C. Giles, Larry E. Halliburton
Faculty Publications
Electron paramagnetic resonance (EPR) is used to identify the singly ionized charge state of the Sn vacancy (V−Sn) in single crystals of Sn2P2S6 (often referred to as SPS). These vacancies, acting as a hole trap, are expected to be important participants in the photorefractive effect observed in undoped SPS crystals. In as-grown crystals, the Sn vacancies are doubly ionized (V2−Sn) with no unpaired spins. They are then converted to a stable EPR-active state when an electron is removed (i.e., a hole is trapped) during an illumination below 100 K …
Increasing Tetrahydrobiopterin In Cardiomyocytes Adversely Affects Cardiac Redox State And Mitochondrial Function Independently Of Changes In No Production, Savitha Sethumadhavan, Jennifer Whitsett, Brian Bennett, Irina A. Ionova, Galen M. Pieper, Jeannette Vasquez-Vivar
Increasing Tetrahydrobiopterin In Cardiomyocytes Adversely Affects Cardiac Redox State And Mitochondrial Function Independently Of Changes In No Production, Savitha Sethumadhavan, Jennifer Whitsett, Brian Bennett, Irina A. Ionova, Galen M. Pieper, Jeannette Vasquez-Vivar
Physics Faculty Research and Publications
Tetrahydrobiopterin (BH4) represents a potential strategy for the treatment of cardiac remodeling, fibrosis and/or diastolic dysfunction. The effects of oral treatment with BH4 (Sapropterin™ or Kuvan™) are however dose-limiting with high dose negating functional improvements. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart. Using this model, we aimed to establish the cardiomyocyte-specific responses to high levels of BH4. Quantification of BH4 and BH2 in mGCH transgenic hearts showed age-based variations in BH4:BH2 ratios. Hearts of mice (months) have lower BH4:BH2 ratios …