Physics Commons^™

Development Of A Novel Technique For Predicting Tumor Response In Adaptive Radiation Therapy, Rebecca Marie Seibert

Doctoral Dissertations

This dissertation concentrates on the introduction of Predictive Adaptive Radiation Therapy (PART) as a potential method to improve cancer treatment. PART is a novel technique that utilizes volumetric image-guided radiation therapy treatment (IGRT) data to actively predict the tumor response to therapy and estimate clinical outcomes during the course of treatment. To implement PART, a patient database containing IGRT image data for 40 lesions obtained from patients who were imaged and treated with helical tomotherapy was constructed. The data was then modeled using locally weighted regression. This model predicts future tumor volumes and masses and the associated confidence intervals based …

Secondary Light Particle Data Base Development Using A Thermodynamic Coalescence Model, Mahmoud Pourarsalan

Doctoral Dissertations

ABSTRACT

As heavy ions are transported through shielding and interact with shielding materials accurate values of total, elastic scattering, reactions cross sections and angular distributions of the emitted nucleons, light high energy particles such as deuteron, triton, helion, alpha particles and other heavy ions are required in order to design appropriate and adequate shielding to protect the human crews and instruments from ionizing radiations during long duration space missions. Double-differential (energy and angle) light energetic particle production cross sections must be known for ion energies from tens of MeV/nucleon to tens of GeV/nucleon for all emitted light energetic particles for …

Derivation Of Correction Terms To The Eikonal Approximations In The Formulation Of Analytical Abrasion-Ablation Model, Santosh Bhatt

Doctoral Dissertations

Analytical models for the quantitative predictions of spectra from the neutrons and light ions produced from the high energy, heavy ion (HZE) reactions are extremely important in assessment of the radiation damage during long duration deep space missions, and for various accelerator applications. The fundamental physics of the secondary particle production and transport from these HZE reactions is described using the abrasion-ablation model. The abrasion part of the model is based on the Glauber multiple scattering theory while the ablation process is based on statistical decay based on an evaporation model. The current formulations for the abrasion process are based …