Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Physics
Distribution Coefficients Of Ionized And Un-Ionized Halogenated Phenols In An Octanol-Water System And Their Relationship To Molecular Structure, Sven Hensler
Dissertations and Theses
Life supporting biological membranes are barriers to toxic chemicals. One of the factors determining the toxicity of chemical compounds is their distribution between membranes and their an environment. An octanol-water system is frequently used as a model for biological membranes to estimate the toxic potency of environmental pollutants. The distribution of a chemical between the octanol and the water phase is described by the octanol-water partition coefficient KOW. This study is concerned with the relationship between KOW and the molecular structure of the toxic chemical.
In the study the following trihalophenols were included: 2,4,6-trifluorophenol (TriFP), 2,4,6-trichlorophenol (TriCP); …
Distribution Of Ionized And Neutral Halogenated Phenols In An Octanol-Water Membrane Model System, Robert Word
Distribution Of Ionized And Neutral Halogenated Phenols In An Octanol-Water Membrane Model System, Robert Word
Dissertations and Theses
The accumulation of xenobiotics, such as halogenated phenols, in soils, sediments, and living organisms is primarily a partitioning process between an aquatic and organic phase. It is traditional to use a bulk octanol-water system to model the partitioning of a compound between complex biological lipid membranes and aqueous media. The octanol-water partition coefficient KOW successfully approximates the lipid membrane-water partition coefficient KLipW of neutral compounds. However, the ionized species of substituted phenols were shown to have a higher affinity for lipid membranes than predicted from octanol-water results.
Data on the octanol-water partition coefficients of molecular ions is limited. …