Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physics
Effects Of Solvent Used For Fabrication On Drug Loading And Release Kinetics Of Electrosprayed Temozolomide-Loaded Plga Microparticles For The Treatment Of Glioblastoma, Daniel A. Rodriguez De Anda, Nareg Ohannesian, Karen S. Martirosyan, Sue Anne Chew
Effects Of Solvent Used For Fabrication On Drug Loading And Release Kinetics Of Electrosprayed Temozolomide-Loaded Plga Microparticles For The Treatment Of Glioblastoma, Daniel A. Rodriguez De Anda, Nareg Ohannesian, Karen S. Martirosyan, Sue Anne Chew
Physics and Astronomy Faculty Publications and Presentations
Glioblastoma multiforme (GBM) is the most common and invasive form of malignant brain tumors and despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with GBM still remains poor. Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i.e., dichloromethane and acetonitrile) used for the fabrication of electrosprayed TMZ-loaded poly(lactic-co-glycolic acid) (PLGA) on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were investigated. The results from this study demonstrated that by using a larger volume of a solvent …