Physics Commons^™

Folding Of Bovine Pancreatic Trypsin Inhibitor (Bpti) Is Faster Using Aromatic Thiols And Their Corresponding Disulfides, Ram Prasad Marahatta

FIU Electronic Theses and Dissertations

Improvement in the in vitro oxidative folding of disulfide-containing proteins, such as extracellular and pharmaceutically important proteins, is required. Traditional folding methods using small molecule aliphatic thiol and disulfide, such as glutathione (GSH) and glutathione disulfide (GSSG) are slow and low yielding. Small molecule aromatic thiols and disulfides show great potentiality because aromatic thiols have low pKa values, close to the thiol pKa of protein disulfide isomerase (PDI), higher nucleophilicity and good leaving group ability. Our studies showed that thiols with a positively charged group, quaternary ammonium salts (QAS), are better than thiols with negatively charged groups such as phosphonic …

Antibaryon Photoproduction Using Clas At Jefferson Lab, William B. Phelps

FIU Electronic Theses and Dissertations

Antibaryon production has been investigated since the advent of nuclear

physics, largely motivated by the potential for baryon-antibaryon bound states.

Due to the recent availability of high statistics experiments there has been a

renewed interest in how antibaryons are created in photoproduction. The g12

(E04-005) experiment conducted at Thomas Jefferson National Accelerator Fa-

cility used the CEBAF Large Acceptance Spectrometer to provide the world’s

largest dataset for baryon-antibaryon photoproduction on a liquid hydrogen tar-

get. The focus of this work is to investigate the photoproduction mechanism of

γp → ppp ̄ through detailed differential cross section measurements from 3.95

to …

Examining The Relationships Between Gender Role Congruity, Identity, And The Choice To Persist For Women In Undergraduate Physics Majors, Bronwen Bares Pelaez

FIU Electronic Theses and Dissertations

Persistent gender disparity limits the available contributors to advancing some science, technology, engineering, and math (STEM) fields. While higher education can be an influential time-point for ensuring adequate participation, many physics programs across the U.S. have few women in classroom or lab settings. Prior research indicates that these women face considerable barriers. For university students, faculty, and administration to appropriately address these issues, it is important to understand the experiences of women as they navigate male-dominated STEM fields.

This explanatory sequential mixed methods study explored undergraduate female physics majors’ experiences with their male-dominated academic and research spaces in the U.S. …

Resilient And Real-Time Control For The Optimum Management Of Hybrid Energy Storage Systems With Distributed Dynamic Demands, Christopher R. Lashway

FIU Electronic Theses and Dissertations

A continuous increase in demands from the utility grid and traction applications have steered public attention toward the integration of energy storage (ES) and hybrid ES (HESS) solutions. Modern technologies are no longer limited to batteries, but can include supercapacitors (SC) and flywheel electromechanical ES well. However, insufficient control and algorithms to monitor these devices can result in a wide range of operational issues. A modern day control platform must have a deep understanding of the source. In this dissertation, specialized modular Energy Storage Management Controllers (ESMC) were developed to interface with a variety of ES devices. The EMSC provides …

Describing And Mapping The Interactions Between Student Affective Factors Related To Persistence In Science, Physics, And Engineering, Jacqueline Doyle

FIU Electronic Theses and Dissertations

This dissertation explores how students’ beliefs and attitudes interact with their identities as physics people, motivated by calls to increase participation in science, technology, engineering, and mathematics (STEM) careers. This work combines several theoretical frameworks, including Identity theory, Future Time Perspective theory, and other personality traits to investigate associations between these factors. An enriched understanding of how these attitudinal factors are associated with each other extends prior models of identity and link theoretical frameworks used in psychological and educational research. The research uses a series of quantitative and qualitative methodologies, including linear and logistic regression analysis, thematic interview analysis, and …

Behavioral And Neural Mechanisms Of Social Heterogeneity In Attention Deficit/Hyperactivity Disorder, Kailey Macnamara

FIU Electronic Theses and Dissertations

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common child-onset neurodevelopment disorders, affecting 5% of children in the United States (American Psychiatric Association, 2013). Treatment matching in ADHD is difficult and unsatisfactory; the same general treatment algorithm is recommended for all children. It is therefore important to consider the development of specialized treatment programs based on a variety of behavioral and neurological biomarkers. Unfortunately, due to its multi-faceted classification, the heterogeneity of this behavioral disorder is under-investigated (Costa Dias et al., 2015). Scientific research in this area is especially limited as the severity of ADHD goes undiagnosed, children tend to …

Multinucleon Short-Range Correlation Model For Nuclear Spectral Functions, Oswaldo Artiles

FIU Electronic Theses and Dissertations

The main goal of the research presented in my dissertation was to develop a theoretical model for relativistic nuclear spectral functions at high missing momenta and removal energies based on the multi-nucleon short-range correlation (SRC) model. The nuclear spectral functions are necessary for the description of high energy nuclear processes currently being studied at different labs such as JLAB, LHC and FNAL.

The model followed the effective Feynman diagrammatic approach in order to ac-count for the relativistic effects important in the SRC domain. In addition to the two-nucleon (2N) SRC with center of mass motion contribution, the contribution of the …

Tunable, Room Temperature Thz Emitters Based On Nonlinear Photonics, Raju Sinha

FIU Electronic Theses and Dissertations

The Terahertz (10¹² Hz) region of the electromagnetic spectrum covers the frequency range from roughly 300 GHz to 10 THz, which is in between the microwave and infrared regimes. The increasing interest in the development of ultra-compact, tunable room temperature Terahertz (THz) emitters with wide-range tunability has stimulated in-depth studies of different mechanisms of THz generation in the past decade due to its various potential applications such as biomedical diagnosis, security screening, chemical identification, life sciences and very high speed wireless communication. Despite the tremendous research and development efforts, all the available state-of-the-art THz emitters suffer from either being …

Scanning Ion Conductance Microscopy For Single Cell Imaging And Analysis, Namuna Panday

FIU Electronic Theses and Dissertations

Most biological experiments are performed on an ensemble of cells under the assumption that all cells are identical. However, recent evidence from single cells studies reveals that this assumption is incorrect. Individual cells within the same generation may differ dramatically, and these differences have important consequences for the health and function of the entire living body. I have used Scanning Ion Conductance Microscopy (SICM) for imaging and analysis of topographical change of single cell membrane, which is difficult to be revealed by optical microscopes. Morphological change in the fixed and live HeLa cell membrane during endocytosis of conjugated polymer nanoparticles …

Molecular Dynamics Investigations Of Structural Conversions In Transformer Proteins, Jeevan Gc

FIU Electronic Theses and Dissertations

Multifunctional proteins that undergo major structural changes to perform different functions are known as “Transformer Proteins”, which is a recently identified class of proteins. One such protein that shows a remarkable structural plasticity and has two distinct functions is the transcription antiterminator, RfaH. Depending on the interactions between its N-terminal domain and its C-terminal domain, the RfaH CTD exists as either an all-α-helix bundle or all-β-barrel structure. Another example of a transformer protein is the Ebola virus protein VP40 (eVP40), which exists in different conformations and oligomeric states (dimer, hexamer, and octamer), depending on the required function.I performed Molecular Dynamics …

The Interactions Of Relationships, Interest, And Self-Efficacy In Undergraduate Physics, Remy Dou

FIU Electronic Theses and Dissertations

This collected papers dissertation explores students’ academic interactions in an active learning, introductory physics settings as they relate to the development of physics self-efficacy and interest. The motivation for this work extends from the national call to increase participation of students in the pursuit of science, technology, engineering, and mathematics (STEM) careers. Self-efficacy and interest are factors that play prominent roles in popular, evidence-based, career theories, including the Social cognitive career theory (SCCT) and the identity framework. Understanding how these constructs develop in light of the most pervasive characteristic of the active learning introductory physics classroom (i.e., peer-to-peer interactions) has …