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All HMC Faculty Publications and Research

Optics

Frequency-domain photon migration

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Full-Text Articles in Physics

Portable, High-Bandwidth Frequency-Domain Photon Migration Instrument For Tissue Spectroscopy, Steen J. Madsen, Eric R. Anderson, Richard C. Haskell, Bruce J. Tromberg Dec 1994

Portable, High-Bandwidth Frequency-Domain Photon Migration Instrument For Tissue Spectroscopy, Steen J. Madsen, Eric R. Anderson, Richard C. Haskell, Bruce J. Tromberg

All HMC Faculty Publications and Research

We describe a novel frequency-domain photon migration instrument employing direct diode laser modulation and avalanche photodiode detection, which is capable of noninvasively determinating the optical properties of biological tissues in near real time. An infinite medium diffusion model was used to extract absorption and transport scattering coefficients from 300-kHz to 800-MHz photon-density wave phase data. Optical properties measured in tissue-simulating solutions at 670 nm agreed to within 10% of those expected.


Properties Of Photon Density Waves In Multiple-Scattering Media, Bruce J. Tromberg, Lars O. Svaasand, Tsong-Tseh Tsay, Richard C. Haskell Feb 1993

Properties Of Photon Density Waves In Multiple-Scattering Media, Bruce J. Tromberg, Lars O. Svaasand, Tsong-Tseh Tsay, Richard C. Haskell

All HMC Faculty Publications and Research

Amplitude-modulated light launched into multiple-scattering media, e.g., tissue, results in the propagation of density waves of diffuse photons. Photon density wave characteristics in turn depend on modulation frequency (ω) and media optical properties. The damped spherical wave solutions to the homogeneous form of the diffusion equation suggest two distinct regimes of behavior: (1) a highfrequency dispersion regime where density wave phase velocity Vp has a ω dependence and (2) a low-frequency domain where Vp is frequency independent. Optical properties are determined for various tissue phantoms by fitting the recorded phase (Φ) and modulation (m) response to simple ...