Physics Commons^™

Pulsatile Flow Through Idealized Renal Tubules: Fluid-Structure Interaction And Dynamic Pathologies, Niksa Praljak, Shawn D. Ryan, Andrew Resnick

Mathematics and Statistics Faculty Publications

Kidney tubules are lined with flow-sensing structures, yet information about the flow itself is not easily obtained. We aim to generate a multiscale biomechanical model for analyzing fluid flow and fluid-structure interactions within an elastic kidney tubule when the driving pressure is pulsatile. We developed a two-dimensional macroscopic mathematical model of a single fluid-filled tubule corresponding to a distal nephron segment and determined both flow dynamics and wall strains over a range of driving frequencies and wall compliances using finite-element analysis. The results presented here demonstrate good agreement with available analytical solutions and form a foundation for future inclusion of …