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Acyl-Chain Mismatch Driven Superlattice Arrangements In Dppc/Dlpc/Cholesterol Bilayers, Brian Cannon, Anthony Lewis, Pentti Somerharju, Jorma Virtanen, Juyang Huang, Kwan H. Cheng
Acyl-Chain Mismatch Driven Superlattice Arrangements In Dppc/Dlpc/Cholesterol Bilayers, Brian Cannon, Anthony Lewis, Pentti Somerharju, Jorma Virtanen, Juyang Huang, Kwan H. Cheng
Physics and Astronomy Faculty Research
Fluorescence and infrared spectroscopy and cholesterol oxidase activity were employed to investigate the effect of phosphatidylcholine (PC) acyl chain length mismatch on the lateral organizations of lipids in liquid-ordered dipalmitoyl-PC/dilauroyl-PC/cholesterol (DPPC/DLPC/CHOL) bilayers. Plots of steady-state fluorescence emission anisotropy of diphenylhexatriene (DPH) labeled PC (DPH-PC) embedded in the DPPC/DLPC/CHOL bilayers revealed significant peaks at several DPPC mole fractions (YDPPC) when the cholesterol mole fraction (XCHOL) was fixed to particular values. Analogously, the DPH-PC anisotropy peaked at several critical XCHOL’s when YDPPC was fixed. Acyl chain C−H and C═O vibrational peak frequencies of …