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Articles 1 - 5 of 5
Full-Text Articles in Physics
Magnetization Reversal In Ferromagnetic Spirals Via Domain Wall Motion, Ryan D. Schumm, Andrew Kunz
Magnetization Reversal In Ferromagnetic Spirals Via Domain Wall Motion, Ryan D. Schumm, Andrew Kunz
Physics Faculty Research and Publications
Domain wall dynamics have been investigated in a variety of ferromagnetic nanostructures for potential applications in logic, sensing, and recording. We present a combination of analytic and simulated results describing the reliable field driven motion of a domain wall through the arms of a ferromagnetic spiral nanowire. The spiral geometry is capable of taking advantage of the benefits of both straight and circular wires. Measurements of the in-plane components of the spirals' magnetization can be used to determine the angular location of the domain wall, impacting the magnetoresistive applications dependent on the domain wall location. The spirals' magnetization components are …
Teaching The Basics Of Reactive Oxygen Species And Their Relevance To Cancer Biology: Mitochondrial Reactive Oxygen Species Detection, Redox Signaling, And Targeted Therapies, Balaraman Kalyanaraman, Gang Cheng, Micael Hardy, Olivier Ouari, Brian Bennett, Jacek Zielonka
Teaching The Basics Of Reactive Oxygen Species And Their Relevance To Cancer Biology: Mitochondrial Reactive Oxygen Species Detection, Redox Signaling, And Targeted Therapies, Balaraman Kalyanaraman, Gang Cheng, Micael Hardy, Olivier Ouari, Brian Bennett, Jacek Zielonka
Physics Faculty Research and Publications
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation, tumor progression, and metastasis). Of the many cellular sources of ROS generation, the mitochondria and the NADPH oxidase family of enzymes are possibly the most prevalent intracellular sources. In this article, we discuss the methodologies to detect mitochondria-derived superoxide and hydrogen peroxide using conventional probes as well as newly developed assays and probes, and the necessity of characterizing the diagnostic marker products with HPLC and LC-MS in order to rigorously identify the oxidizing species. The redox signaling roles of mitochondrial ROS, mitochondrial thiolperoxidases, and transcription factors in response to …
Increasing Tetrahydrobiopterin In Cardiomyocytes Adversely Affects Cardiac Redox State And Mitochondrial Function Independently Of Changes In No Production, Savitha Sethumadhavan, Jennifer Whitsett, Brian Bennett, Irina A. Ionova, Galen M. Pieper, Jeannette Vasquez-Vivar
Increasing Tetrahydrobiopterin In Cardiomyocytes Adversely Affects Cardiac Redox State And Mitochondrial Function Independently Of Changes In No Production, Savitha Sethumadhavan, Jennifer Whitsett, Brian Bennett, Irina A. Ionova, Galen M. Pieper, Jeannette Vasquez-Vivar
Physics Faculty Research and Publications
Tetrahydrobiopterin (BH4) represents a potential strategy for the treatment of cardiac remodeling, fibrosis and/or diastolic dysfunction. The effects of oral treatment with BH4 (Sapropterin™ or Kuvan™) are however dose-limiting with high dose negating functional improvements. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart. Using this model, we aimed to establish the cardiomyocyte-specific responses to high levels of BH4. Quantification of BH4 and BH2 in mGCH transgenic hearts showed age-based variations in BH4:BH2 ratios. Hearts of mice (<6 >months) have lower BH4:BH2 …
Potentially Diagnostic Electron Paramagnetic Resonance Spectra Elucidate The Underlying Mechanism Of Mitochondrial Dysfunction In The Deoxyguanosine Kinase Deficient Rat Model Of A Genetic Mitochondrial Dna Depletion Syndrome, Brian Bennett, Daniel Helbling, Hui Meng, Jason Jarzembowski, Aron M. Geurts, Marisa W. Friederich, Johan L.K. Van Hove, Michael W. Lawlor, David P. Dimmock
Potentially Diagnostic Electron Paramagnetic Resonance Spectra Elucidate The Underlying Mechanism Of Mitochondrial Dysfunction In The Deoxyguanosine Kinase Deficient Rat Model Of A Genetic Mitochondrial Dna Depletion Syndrome, Brian Bennett, Daniel Helbling, Hui Meng, Jason Jarzembowski, Aron M. Geurts, Marisa W. Friederich, Johan L.K. Van Hove, Michael W. Lawlor, David P. Dimmock
Physics Faculty Research and Publications
A novel rat model for a well-characterized human mitochondrial disease, mitochondrial DNA depletion syndrome with associated deoxyguanosine kinase (DGUOK) deficiency, is described. The rat model recapitulates the pathologic and biochemical signatures of the human disease. The application of electron paramagnetic (spin) resonance (EPR) spectroscopy to the identification and characterization of respiratory chain abnormalities in the mitochondria from freshly frozen tissue of the mitochondrial disease model rat is introduced. EPR is shown to be a sensitive technique for detecting mitochondrial functional abnormalities in situ and, here, is particularly useful in characterizing the redox state changes and oxidative stress that can result …
Selection And Control Of Individual Domain Walls In Nanowire Arrays Via Asymmetric Depinning Fields, Andrew Kunz, H. Henry Le, Demetrious Kutzke, Jesse Vogeler-Wunsch
Selection And Control Of Individual Domain Walls In Nanowire Arrays Via Asymmetric Depinning Fields, Andrew Kunz, H. Henry Le, Demetrious Kutzke, Jesse Vogeler-Wunsch
Physics Faculty Research and Publications
Artificially inscribed notches are often used to pin domain walls (DWs) in ferromagnetic nanowires. The process of selecting and moving the trapped DW in nanowire arrays is an important step for potential applications. The chirality of a DW leads to a pair of pinning positions at the inscribed notches, which can be modeled by a symmetric double well. The depinning field depends on the side of the well, the DW is trapped with respect to the applied field direction, and the DWs can also be transitioned between the two wells without depinning. We demonstrate how manipulating the double well improves …