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Articles 1 - 7 of 7
Full-Text Articles in Physics
Development And Application Of Hybrid Wray-Agarwal Turbulence Model And Large-Eddy Simulation, Xu Han
Development And Application Of Hybrid Wray-Agarwal Turbulence Model And Large-Eddy Simulation, Xu Han
McKelvey School of Engineering Theses & Dissertations
Rapid development in computing power in past five decades along with the development and progress in building blocks of Computational Fluid Dynamics (CFD) technology has made CFD an indispensable tool for modern engineering analysis and design of fluid-based products and systems. For CFD analysis, Reynolds-Averaged Navier-Stokes (RANS) equations are currently the most widely used fluid equations in the industry. RANS methods require modeling of turbulence effect (i.e. turbulence modeling) based on empirical relations and therefore often produce low accuracy results for many flows. In recent years, the Large Eddy Simulation (LES) approach has been developed which has shown promise of …
In Vivo Vascular Imaging With Photoacoustic Microscopy, Hsun-Chia Hsu
In Vivo Vascular Imaging With Photoacoustic Microscopy, Hsun-Chia Hsu
McKelvey School of Engineering Theses & Dissertations
Photoacoustic (PA) tomography (PAT) has received extensive attention in the last decade for its capability to provide label-free structural and functional imaging in biological tissue with highly scalable spatial resolution and penetration depth. Compared to modern optical modalities, PAT offers speckle-free images and is more sensitive to optical absorption contrast (with 100% relative sensitivity). By implementing different regimes of optical wavelength, PAT can be used to image diverse light-absorbing biomolecules. For example, hemoglobin is of particular interest in the visible wavelength regime owing to its dominant absorption, and lipids and water are more commonly studied in the near-infrared regime.
In …
Fluorescence Guided Tumor Imaging: Foundations For Translational Applications, Jessica P. Miller
Fluorescence Guided Tumor Imaging: Foundations For Translational Applications, Jessica P. Miller
McKelvey School of Engineering Theses & Dissertations
Optical imaging for medical applications is a growing field, and it has the potential to improve medical outcomes through its increased sensitivity and specificity, lower cost, and small instrumentation footprint as compared to other imaging modalities. The method holds great promise, ranging from direct clinical use as a diagnostic or therapeutic tool, to pre-clinical applications for increased understanding of pathology. Additionally, optical imaging uses non-ionizing radiation which is safe for patients, so it can be used for repeated imaging procedures to monitor therapy, guide treatment, and provide real-time feedback. The versatile features of fluorescence-based optical imaging make it suited for …
Developing Wavefront Shaping Techniques For Focusing Through Highly Dynamic Scattering Media, Ashton Hemphill
Developing Wavefront Shaping Techniques For Focusing Through Highly Dynamic Scattering Media, Ashton Hemphill
McKelvey School of Engineering Theses & Dissertations
One of the prime limiting factors of optical imaging in biological applications is the diffusion of light by tissue, which prevents focusing at depths greater than the optical diffusion limit of ~1 mm in soft tissue. This greatly restricts the utility of optical diagnostic and therapeutic techniques, such as optogenetics, microsurgery, optical tweezing, and phototherapy of deep tissue, which require focused light in order to function. Wavefront shaping extends the depth at which optical focusing may be achieved by compensating for phase distortions induced by scattering, allowing for focusing through constructive interference.
However, due to physiological motion, scattering of light …
Developing Photoacoustic Tomography Devices For Translational Medicine And Basic Science Research, Tsz Wai Wong
Developing Photoacoustic Tomography Devices For Translational Medicine And Basic Science Research, Tsz Wai Wong
McKelvey School of Engineering Theses & Dissertations
Photoacoustic (PA) tomography (PAT) provides volumetric images of biological tissue with scalable spatial resolutions and imaging depths, while preserving the same imaging contrast—optical absorption. Taking the advantage of its 100% sensitivity to optical absorption, PAT has been widely applied in structural, functional, and molecular imaging, with both endogenous and exogenous contrasts, at superior depths than pure optical methods. Intuitively, hemoglobin has been the most commonly studied biomolecule in PAT due to its strong absorption in the visible wavelength regime.
One of the main focuses of this dissertation is to investigate an underexplored wavelength regime—ultraviolet (UV), which allows us to image …
Novel Sensing Mechanisms For Chemical And Bio-Sensing Using Whispering Gallery Mode Microresonators, He Huang
Novel Sensing Mechanisms For Chemical And Bio-Sensing Using Whispering Gallery Mode Microresonators, He Huang
McKelvey School of Engineering Theses & Dissertations
Due to their ultra-high quality factor and small mode volume, whispering gallery mode (WGM) microresonators have proven to have exceptional sensing capabilities, with single particle level sensitivity to virions, proteins, and nucleic acids. Current sensing mechanisms rely on measuring the changes in the transmission spectrum of the resonator upon adsorption of the analyte on the surface of the resonator, appearing as either shift, splitting, or broadening of the resonance mode, all of which measure the polarizability of adsorbed analytes. In this dissertation, we present two new sensing mechanisms for WGM microresonators: the measurement of a dynamic chemical reaction around the …
Numerical Simulation Of A High Strain Rate Biaxial Compression Apparatus, Michael Lagieski
Numerical Simulation Of A High Strain Rate Biaxial Compression Apparatus, Michael Lagieski
McKelvey School of Engineering Theses & Dissertations
Few experimental methods today are capable of exploring the strength of materials at high strain rates (105 s-1). Those that are capable, such as the Split Hopkinson Bar, Taylor Anvil and Plate Impact suffer from instability and are generally limited to one dimensional wave propagation. Of particular interest is material response under biaxial compression, similar to that seen in inertial confinement fusion. Laser fusion fuel pellets typically undergo large strain rates as well as plastic deformation and non-linear behavior. This work briefly outlines an experimental procedure designed to replicate these large strain rates under biaxial compression using …