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Evaluation Of Pulmonary And Systemic Toxicity Following Lung Exposure To Graphite Nanoplates: A Member Of The Graphene-Based Nanomaterial Family, Jenny R. Roberts, Robert R. Mercer, Aleksandr B. Stefaniak, Mohindar S. Seehra, Usha K. Geddam, Ishrat S. Chaudhuri, Angelos Kyrlidis, Vamsi K. Kodali, Tina Sager, Allison Kenyon, Suzan A. Bilgesu, Tracy Eye, James F. Scabilloni, Stephen S. Leonard, Natalie R. Fix, Diane Schwegler-Berry, Breanne Y. Farris, Michael G. Wolfarth, Dale W. Porter, Vincent Castranova, Aaron Erdely
Evaluation Of Pulmonary And Systemic Toxicity Following Lung Exposure To Graphite Nanoplates: A Member Of The Graphene-Based Nanomaterial Family, Jenny R. Roberts, Robert R. Mercer, Aleksandr B. Stefaniak, Mohindar S. Seehra, Usha K. Geddam, Ishrat S. Chaudhuri, Angelos Kyrlidis, Vamsi K. Kodali, Tina Sager, Allison Kenyon, Suzan A. Bilgesu, Tracy Eye, James F. Scabilloni, Stephen S. Leonard, Natalie R. Fix, Diane Schwegler-Berry, Breanne Y. Farris, Michael G. Wolfarth, Dale W. Porter, Vincent Castranova, Aaron Erdely
Faculty & Staff Scholarship
Background: Graphene, a monolayer of carbon, is an engineered nanomaterial (ENM) with physical and chemical properties that may offer application advantages over other carbonaceous ENMs, such as carbon nanotubes (CNT). The goal of this study was to comparatively assess pulmonary and systemic toxicity of graphite nanoplates, a member of the graphene-based nanomaterial family, with respect to nanoplate size.
Methods: Three sizes of graphite nanoplates [20 μm lateral (Gr20), 5 μm lateral (Gr5), and <2 >μm lateral (Gr1)] ranging from 8–25 nm in thickness were characterized for difference in surface area, structure,, zeta potential, and agglomeration in dispersion medium, the vehicle for …