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Implementation,Validation And Application Of An Automated Motion Correction Algorithm In Hepatic Perfusion Ct For Image-Guided Radiotherapy, Nikolaj Kg Jensen
Implementation,Validation And Application Of An Automated Motion Correction Algorithm In Hepatic Perfusion Ct For Image-Guided Radiotherapy, Nikolaj Kg Jensen
Electronic Thesis and Dissertation Repository
Functional imaging holds promise in guiding, evaluating and predicting efficacy of cancer treatment. Perfusion imaging provides high resolution functional information generated by applying a model to a dynamic series of contrast enhanced anatomical images.
The objectives of this thesis are: 1) to develop and validate a registration algorithm to reduce breathing motion artifacts in hepatic perfusion CT, and 2) to evaluate the potential of perfusion CT to improve radiotherapy of liver cancer.
An automated one-dimensional correlation-based registration algorithm was developed and validated in phantom and pig studies and against manual registration of patient scans. This algorithm was used to register …