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Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
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Terahertz spectroscopy has found use as an analytical tool in determining chemical composition of exhaled human breath. This thesis demonstrates a novel application of this technology - analytical sensing of gaseous metabolic products of several types of human cell cultures. An innovative experimental system was developed for probing cellular metabolism using terahertz [THz] rotational spectroscopy. Gaseous emissions of cell cultures were analyzed and compared between several cell types. Cancerous and healthy lung cells as well as cancerous liver cells were studied. This technique carries a lot of promise as a noninvasive method of distinguishing between cell types and identifying cell …
Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
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Terahertz spectroscopy has found use as an analytical tool in determining chemical composition of exhaled human breath. This thesis demonstrates a novel application of this technology - analytical sensing of gaseous metabolic products of several types of human cell cultures. An innovative experimental system was developed for probing cellular metabolism using terahertz [THz] rotational spectroscopy. Gaseous emissions of cell cultures were analyzed and compared between several cell types. Cancerous and healthy lung cells as well as cancerous liver cells were studied. This technique carries a lot of promise as a noninvasive method of distinguishing between cell types and identifying cell …
Terahertz Spectroscopic Breath Analysis As A Viable Analytical Chemical Sensing Technique, Robert M. Schueler
Terahertz Spectroscopic Breath Analysis As A Viable Analytical Chemical Sensing Technique, Robert M. Schueler
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The ability to quantify trace chemicals in human breath enables the possibility of identifying breath biomarkers to aid in diagnosis. The vast majority of the studies in the analytical breath analysis rely on GC-MS techniques for quantification of the human breath composition1,2,3,4. THz spectroscopy of breath is rapid, sensitive, and highly specific molecular identification in complex mixtures containing 10-100 analytes with near `absolute' specificity. THz spectroscopic breath analyzers require chemical preconcentration. A newly developed custom preconcentrator was constructed and compared in its performance to a commercial system. Unlike the commercial counterpart, the new system does not require cryogenic liquids, is …
Millimeter – Wave/Terahertz Chirped Michelson Interferometer Techniques For Sub Surface Sensing, Dinesh Amal Mirando
Millimeter – Wave/Terahertz Chirped Michelson Interferometer Techniques For Sub Surface Sensing, Dinesh Amal Mirando
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Over the last couple of decades, the field of millimeter-wave (mmW) and terahertz (THz) radiation has seen an accelerated growth thanks to developments in high quality mmW/THz sensors. These developments have contributed to many useful applications in the fields of medicine, security, construction, etc. Non-destructive evaluations such as the detection of defects in materials is currently one of the major applications of mmW/THz radiation. These evaluations are performed using mmW/THz continuous-wave radar systems. In this study, we discuss how Frequency Modulated Continuous Wave (FMCW) techniques can enhance sensing applications through the use of a Michelson interferometer. This allows multiple objects …
Analytical Chemical Sensing Using High Resolution Terahertz/Submillimeter Wave Spectroscopy, Benjamin L. Moran
Analytical Chemical Sensing Using High Resolution Terahertz/Submillimeter Wave Spectroscopy, Benjamin L. Moran
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A highly sensitive and selective Terahertz gas sensor used to analyze a complex mixture of Volatile Organic Compounds (VOCs) has been developed. To best demonstrate analytical capabilities of a THz chemical sensor, we chose to perform analytical quantitative analysis of a certified gas mixture using a prototype gas phase chemical sensor that couples a commercial preconcentration system (Entech 7100A) to a custom high resolution THz spectrometer. A Method TO-14A certified mixture of thirty-nine VOCs was purchased. Twenty-six of the thirty-nine chemicals were identified as suitable for THz spectroscopic detection. The Entech 7100A system is designed and marketed as an inlet …
Characterization Of Structured Nanomaterials Using Terahertz Frequency Radiation, Andrew John Niklas
Characterization Of Structured Nanomaterials Using Terahertz Frequency Radiation, Andrew John Niklas
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Measurements that use terahertz frequency radiation to characterize materials are beneficial for scientists trying to determine the physical parameters that govern the interaction of electromagnetic waves and matter at those frequencies. Results will be presented of time domain terahertz spectroscopy measurements taken in forward and backward scattering directions from vertically aligned arrays of multi-walled carbon nanotubes and thin films of perforated copper. The intent of this research is to both corroborate results from independent research groups conducting similar experiments and to further increase understanding in the scientific community with respect to carbon nanotube reflection phenomena at terahertz frequencies.