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Full-Text Articles in Physics
Evaluation And Adaptation Of Live-Cell Interferometry For Applications In Basic, Translational, And Clinical Research, Kevin A. Leslie
Evaluation And Adaptation Of Live-Cell Interferometry For Applications In Basic, Translational, And Clinical Research, Kevin A. Leslie
Theses and Dissertations
Cell mass is an important indicator of cell health and status. A diverse set of techniques have been developed to precisely measure the masses of single cells, with varying degrees of technical complexity and throughput. Here, the development of a non-invasive, label-free optical technique, termed Live-Cell Interferometry (LCI), is described. Several applications are presented, including an evaluation of LCI’s utility for assessing drug response heterogeneity in patient-derived melanoma lines and the measurement of CD3+ T cell kinetics during hematopoietic stem cell transplantation. The characterization of mast cells during degranulation, the measurement of viral reactivation kinetics in Kaposi’s Sarcoma, and drug …
Integration Of Vmc++ Into A Commercial Treatment Planning System, Joseph Kingsley Gardner
Integration Of Vmc++ Into A Commercial Treatment Planning System, Joseph Kingsley Gardner
Theses and Dissertations
Recently, there has been interest to integrate VMC++ into the commercial treatment planning system at VCU as another Monte Carlo code option, since it has been shown to increase efficiency dramatically without introducing a significant amount of systematic error. Also, independent validation of VMC++ for photon beams is of interest since this has not been performed previously in literature. This study included several tests required to integrate VMC++. Output factor normalization was performed and found to agree with experiment to within 1% for all field sizes except 1x1 cm2. Geometric validation was successful. Dosimetric validation was performed with respect to …