Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Physics
Characterization Of The Effects Of Radiation On Skeletal And Smooth Muscle Cells, Lori Caldwell, Charles Harding, Jr Dennison, Elizabeth Vargis
Characterization Of The Effects Of Radiation On Skeletal And Smooth Muscle Cells, Lori Caldwell, Charles Harding, Jr Dennison, Elizabeth Vargis
Posters
Muscular atrophy is a serious issue for extended spaceflight. Understanding and preventing the role of ionizing radiation in skeletal muscle loss would preserve the strength and endurance of astronauts and enable longer duration space travel and exploration. Irradiation was performed in the USU material physics group's Space Suvivability Test Chamber. C2C12 and CRL-1999 cells were exposed to dosages ranging from 0.5 - 36.8 Gy. Cell viability and growth rate were measured immediately following irradiation.
Characterizing The Effects Of Radiation On Muscle Cells, Lori Caldwell, Elizabeth Vargis, Charles Harding, Jr Dennison
Characterizing The Effects Of Radiation On Muscle Cells, Lori Caldwell, Elizabeth Vargis, Charles Harding, Jr Dennison
Posters
One of the primary concerns for those spending time in low gravity and high radiation environments is muscle atrophy. A major cause of muscular atrophy is oxidative stress which is amplified by increased levels of ionizing radiation during spaceflight. Additionally, high levels of radiation can damage DNA, increasing the risk of cancer. Utah State University’s Space Environment Test Facility was used to irradiate C2C12 myoblasts and human vascular endothelial cells with a beta-radiation dosage mimicking that on the International Space Station and a 3-year deep space mission.
Characterizing The Effects Of Radiation On Muscle Cells, Lori Caldwell, Charles Harding, Jr Dennison, Elizabeth Vargis
Characterizing The Effects Of Radiation On Muscle Cells, Lori Caldwell, Charles Harding, Jr Dennison, Elizabeth Vargis
Posters
As longer space missions become more desirable to public and private institutions, the physiological impact on astronauts must be considered. One of the primary concerns for those spending time in low gravity and high radiation environments is muscle atrophy. A major cause of muscular atrophy is oxidative stress which is amplified by increased levels of ionizing radiation during spaceflight. Additionally, high levels of radiation can damage DNA, increasing the risk of cancer. Utah State University’s Space Environment Test Facility was used to irradiate C2C12 myoblasts and human vascular endothelial cells with a dosage mimicking that on the International Space Station …