Physics Commons^™

Mechanisms Of Hemolysis-Associated Platelet Activation, Christine C. Helms, M. Marvel, W. Zhao, M. Stahle, R. Vest, G. J. Kato, J. S. Lee, G. Christ, M. T. Gladwin, R. R. Hantgan, D. B. Kim-Shapiro

Physics Faculty Publications

Background

Intravascular hemolysis occurs after blood transfusion, in hemolytic anemias, and in other conditions, and is associated with hypercoagulable states. Hemolysis has been shown to potently activate platelets in vitro and in vivo, and several mechanisms have been suggested to account for this, including: (i) direct activation by hemoglobin (Hb); (ii) increase in reactive oxygen species (ROS); (iii) scavenging of nitric oxide (NO) by released Hb; and (iv) release of intraerythrocytic ADP.

Objective

To elucidate the mechanism of hemolysis-mediated platelet activation.

Methods

We used flow cytometry to detect PAC-1 binding to activated platelets for in vitro experiments, and a …

Remnants Of Spherical Shell Structures In Deformed Nuclei: The Impact Of An N = 64 Neutron Subshell Closure On The Structure Of N ≈ 90 Gadolinium Nuclei, T. J. Ross, R. O. Hughes, C. W. Beausang, J. M. Allmond, C. Angell, M. S. Basunia, D. L. Bleuel, J. T. Burke, R. J. Casperson, J. Escher, P. Fallon, R. Hatarik, J. Munson, S. Paschalis, M. Petri, L. Phair, J. J. Ressler, N. D. Scielzo

Physics Faculty Publications

Odd-mass gadolinium isotopes around N = 90 were populated by the (p,d) reaction, utilizing 25-MeV protons, resulting in population of low-spin quasineutron states at energies near and below the Fermi surface. Systematics of the single quasineutron levels populated are presented. A large excitation energy gap is observed between levels originating from the 2d_3/2, 1h_11/2, and 3s_1/2 spherical parents (above the N = 64 gap), and the 2d_5/2 (below the gap), indicating that the spherical shell model level spacing is maintained at least to moderate deformations.

Hemoglobin-Mediated Nitric Oxide Signaling, Christine C. Helms, D. B. Kim-Shapiro

Physics Faculty Publications

The rate that hemoglobin reacts with nitric oxide (NO) is limited by how fast NO can diffuse into the heme pocket. The reaction is as fast as any ligand/protein reaction can be and the result, when hemoglobin is in its oxygenated form, is formation of nitrate in what is known as the dioxygenation reaction. As nitrate, at the concentrations made through the deoxygenation reaction, is biologically inert, the only role hemoglobin was once thought to play in NO signaling was to inhibit it. However, there are now several mechanisms that have been discovered by which hemoglobin may preserve, control, and …

Systematic Effects In Interferometric Observations Of The Cosmic Microwave Background Polarization, Ata Karakci, Le Zhang, P. M. Sutter, Emory F. Bunn, Andrei Korotkov, Peter Timbie, Gregory S. Tucker, Benjamin D. Wandelt

Physics Faculty Publications

The detection of the primordial B-mode spectrum of the polarized cosmic microwave background (CMB) signal may provide a probe of inflation. However, observation of such a faint signal requires excellent control of systematic errors. Interferometry proves to be a promising approach for overcoming such a challenge. In this paper we present a complete simulation pipeline of interferometric observations of CMB polarization, including systematic errors. We employ two different methods for obtaining the power spectra from mock data produced by simulated observations: the maximum likelihood method and the method of Gibbs sampling. We show that the results from both methods …

Quadrupole Collectivity In Neutron-Rich Fe And Cr Isotopes, H. L. Crawford, R. M. Clark, P. Fallon, A. O. Macchiavelli, T. Baugher, D. Bazin, C. W. Beausang, J. S. Berryman, D. L. Bleuel, C. M. Campbell, M. Cromaz, G. De Angelis, A. Gade, R. O. Hughes, I. Y. Lee, S. M. Lenzi, F. Nowacki, S. Paschalis, M. Petri, A. Poves, A. Ratkiewicz, T. J. Ross, E. Sahin, D. Weisshaar, K. Wimmer, R. Winkler

Physics Faculty Publications

Intermediate-energy Coulomb excitation measurements are performed on the N≥40 neutron-rich nuclei ^{66, 68}Fe and ⁶⁴Cr. The reduced transition matrix elements providing a direct measure of the quadrupole collectivity B(E2; 2⁺₁→ 0⁺₁) are determined for the first time in ⁶⁸Fe₄₂ and ⁶⁴Cr₄₀ and confirm a previous recoil distance method lifetime measurement in ⁶⁶Fe₄₀. The results are compared to state-of-the-art large-scale shell-model calculations within the full fpgd neutron orbital model space using the Lenzi-Nowacki-Poves-Sieja effective interaction and confirm the results of the calculations that show …

Maximum Likelihood Analysis Of Systematic Errors In Interferometric Observations Of The Cosmic Microwave Background, Le Zhang, Ata Karakci, Paul M. Sutter, Emory F. Bunn, Andrei Korotkov, Peter Timbie, Gregory S. Tucker, Benjamin D. Wandelt

Physics Faculty Publications

We investigate the impact of instrumental systematic errors in interferometric measurements of the cosmic microwave background (CMB) temperature and polarization power spectra. We simulate interferometric CMB observations to generate mock visibilities and estimate power spectra using the statistically optimal maximum likelihood technique. We define a quadratic error measure to determine allowable levels of systematic error that does not induce power spectrum errors beyond a given tolerance. As an example, in this study we focus on differential pointing errors. The effects of other systematics can be simulated by this pipeline in a straightforward manner. We find that, in order to accurately …

Electron Transport In Quantum Dot Chains: Dimensionality Effects And Hopping Conductance, V. P. Kunets, Mariama Rebello Sousa Dias, T. Rembert, M. E. Ware, Y. I. Mazur, V. Lopez-Richard, H. A. Mantooth, G. E. Marques, G. J. Salamo

Physics Faculty Publications

Detailed experimental and theoretical studies of lateral electron transport in a system of quantum dot chains demonstrate the complicated character of the conductance within the chain structure due to the interaction of conduction channels with different dimensionalities. The one-dimensional character of states in the wetting layer results in an anisotropic mobility, while the presence of the zero-dimensional states of the quantum dots leads to enhanced hopping conductance, which affects the low-temperature mobility and demonstrates an anisotropy in the conductance. These phenomena were probed by considering a one-dimensional model of hopping along with band filling effects. Differences between the model and …

High-Spin Study Of The Shell Model Nucleus 88Y49, M. Bunce, P. H. Regan, V. Werner, C. W. Beausang, A. Anagnostatou, M. Bowry, R. J. Casperson, D. Chen, N. Cooper, P. Goddard, R. O. Hughes, G. Ilie, P.J.R. Mason, B. Pauerstein, M. W. Reed, T. J. Ross, E. C. Simpson

Physics Faculty Publications

The near-yrast structure of the near-magic, odd-odd nucleus, ⁸⁸₃₉Y₄₉, has been studied into the high-spin regime. Investigations were performed at the Wright Nuclear Structure Laboratory, Yale University, using the ⁷⁴Ge(¹⁸O,p3n) and ⁷⁶Ge(¹⁸O,p5n) fusion-evaporation reactions at beam energies of 60 and 90 MeV, respectively. Gamma-ray energy coincidence analyses using both double (γ²) and triple (γ³) fold coincidences, together with angular correlation measurements, have been used to extend the previously reported level scheme to an excitation energy of 8.6 MeV and a …

Near-Threshold Neutral Pion Electroproduction At High Momentum Transfers And Generalized Form Factors, P. Khetarpal, Gerard P. Gilfoyle, Et. Al.

Physics Faculty Publications

We report the measurement of near-threshold neutral pion electroproduction cross sections and the extraction of the associated structure functions on the proton in the kinematic range Q² from 2 to 4.5 GeV² and W from 1.08 to 1.16 GeV. These measurements allow us to access the dominant pion-nucleon s-wave multipoles E₀₊ and S₀₊ in the near-threshold region. In the light-cone sum-rule framework (LCSR), these multipoles are related to the generalized form factors G₁^π0p (Q²) and G₂^π0p (Q²). The data are compared to these …