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The Mechanical Properties Of Single Fibrin Fibers, W. Liu, Christine C. Helms, E. A. Sparks, Martin Guthold
The Mechanical Properties Of Single Fibrin Fibers, W. Liu, Christine C. Helms, E. A. Sparks, Martin Guthold
Physics Faculty Publications
Background:
Blood clots perform the mechanical task of stemming the flow of blood.
Objectives:
To advance understanding and realistic modeling of blood clot behavior we determined the mechanical properties of the major structural component of blood clots, fibrin fibers.
Methods:
We used a combined atomic force microscopy (AFM)/fluorescence microscopy technique to determine key mechanical properties of single crosslinked and uncrosslinked fibrin fibers.
Results and conclusions:
Overall, full crosslinking renders fibers less extensible, stiffer, and less elastic than their uncrosslinked counterparts. All fibers showed stress relaxation behavior (time-dependent weakening) with a fast and a slow relaxation time, 2 and 52 s. …