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Review Of Optical Detection Of Single Molecules Beyond The Diffraction And Diffusion Limit Using Plasmonic Nanostructures, Farzia Karim, Todd B. Smith, Chenglong Zhao
Review Of Optical Detection Of Single Molecules Beyond The Diffraction And Diffusion Limit Using Plasmonic Nanostructures, Farzia Karim, Todd B. Smith, Chenglong Zhao
Physics Faculty Publications
Single-molecule detection has become a unique and indispensable tool for the study of molecular motions and interactions at the single-molecule level. Unlike ensemble measurement where the information is averaged, single-molecule analysis yields invaluable information on both the individual molecular properties and their microenvironment. Among the various technologies for the detection of single molecules, the detection with optical methods has many advantages in terms of its high sensitivity, electrical passiveness, and robustness. The recent advances in the engineering of either the excitation light or the solution of the molecules have paved the way for enhanced single-molecule detection. We present recent developments …
Practical Guide To The Realization Of A Convertible Optical Trapping System, Chenglong Zhao
Practical Guide To The Realization Of A Convertible Optical Trapping System, Chenglong Zhao
Physics Faculty Publications
In this article, we provide a detailed guide to the construction of a convertible optical trapping system for either single-beam or counter-propagating trap. The single-beam trap maintains all the functionalities that a conventional optical tweezer has. While the counter-propagating trap allows for the trapping of particles that single-beam trap cannot handle. The counter-propagating trap can be easily switched to a single-beam trap, and vice versa. Therefore, this convertible optical trapping system allows for the trapping and manipulation of particles with a wide variety of sizes and materials.