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Full-Text Articles in Physics
Structure Of Unmodified And Pyroglutamylated Amyloid Beta Peptide In Lipid Membranes, Rowan Hassan
Structure Of Unmodified And Pyroglutamylated Amyloid Beta Peptide In Lipid Membranes, Rowan Hassan
Honors Undergraduate Theses
Alzheimer's Disease (AD) is a devastating neurodegenerative disease that is characterized by brain atrophy, neuronal and synaptic loss, cognitive decline, trouble handling activities of daily life, and ultimately leads to death. Worldwide, at least 30 million people suffer from AD, with 5.8 million suffering in the US alone. Despite extensive basic and clinical research, the underlying molecular mechanisms behind AD remain largely unknown. There are four FDA-approved compounds are used for alleviating symptoms but have no curative potency. The first potentially disease-modifying AD drug, aducanumb, was approved by FDA in June 2021. The main histopathological traits of AD are the …
Structure Difference And Implication To Assembly Morphology Control Of Rous Sarcoma Virus Capsid Protein, John Hastings
Structure Difference And Implication To Assembly Morphology Control Of Rous Sarcoma Virus Capsid Protein, John Hastings
Honors Undergraduate Theses
Rous Sarcoma Virus (RSV) is an avian retrovirus with an enclosing capsid protein (CA) shell. RSV CA is studied due to its similar molecular structure to other retrovirus capsid proteins such as Human Immunodeficiency Virus (HIV). In this project, turbidity assay is used to track the assembly process of RSV CA, while solid state nuclear magnetic resonance (ssNMR) is used to probe the CA structure at a site specific level and investigate the morphology of the spherical structure of the I190V mutated strain of RSV CA. The I190V mutant is a naturally occurring mutation and is able to form into …