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Full-Text Articles in Physics
Phase Velocity Limit Of High-Frequency Photon Density Waves, Richard C. Haskell, Lars O. Svaasand, Steen J. Madsen, Fabio E. Rojas, Ti-Chen C. Feng, Bruce J. Tromberg
Phase Velocity Limit Of High-Frequency Photon Density Waves, Richard C. Haskell, Lars O. Svaasand, Steen J. Madsen, Fabio E. Rojas, Ti-Chen C. Feng, Bruce J. Tromberg
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In frequency-domain photonmigration (FDPM), two factors make high modulation frequencies desirable. First, with frequencies as high as a few GHz, the phase lag versus frequency plot has sufficient curvature to yield both the scattering and absorption coefficients of the tissue under examination. Second, because of increased attenuation, highfrequency photon density waves probe smaller volumes, an asset in small volume in vivo or in vitro studies. This trend toward higher modulation frequencies has led us to reexamine the derivation of the standard diffusion equation (SDE)from the Boltzman transport equation. We find that a second-order time-derivative term, ordinarily neglected in the derivation, …
Optical Property Measurements In Turbid Media Using Frequency Domain Photon Migration, Bruce J. Tromberg, Lars O. Svaasand, Tsong-Tseh Tsay, Richard C. Haskell, Michael W. Berns
Optical Property Measurements In Turbid Media Using Frequency Domain Photon Migration, Bruce J. Tromberg, Lars O. Svaasand, Tsong-Tseh Tsay, Richard C. Haskell, Michael W. Berns
All HMC Faculty Publications and Research
In frequency domain photon migration (FDPM), amplitude-modulated light is launched into a turbid medium, e.g. tissue, which results in the propagation of density waves of diffuse photons. Variations in the optical properties of the medium perturb the phase velocity and amplitude of the diffusing waves. These parameters can be determined by measuring the phase delay and demodulation amplitude of the waves with respect to the source. More specifically, the damped spherical wave solutions to the homogeneous form of the diffusion equation yield expressions for phase (φ) and demodulation (m) as a function of source distance, modulation frequency, absorption coefficient (β), …