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Full-Text Articles in Physics
Characterizing The Design Space Of Oscillatory Biological Networks, Leanne Lunsford, Denise Stephens, Eric Hintz
Characterizing The Design Space Of Oscillatory Biological Networks, Leanne Lunsford, Denise Stephens, Eric Hintz
Journal of Undergraduate Research
Characterizing the relevant parameters of a design space in order to satisfy a specific behavior criterion is an important problem throughout all of science and engineering. In this project we proposed to apply model reduction to the case of biological oscillations involving Michaelis-Menten reactions. By removing irrelevant parameters from a fully connected network we were able to reduce a known problem in systems biology to a more general model. Furthermore, significant progress has been made in applying Manifold Boundary Approximation Method (MBAM) to oscillatory models in systems biology.