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Full-Text Articles in Physics
Protein Conformational Entropy Is Not Slaved To Water, Bryan S Marques, Matthew A Stetz, Christine Jorge, Kathleen G Valentine, A Joshua Wand, Nathaniel V Nucci
Protein Conformational Entropy Is Not Slaved To Water, Bryan S Marques, Matthew A Stetz, Christine Jorge, Kathleen G Valentine, A Joshua Wand, Nathaniel V Nucci
Faculty Scholarship for the College of Science & Mathematics
Conformational entropy can be an important element of the thermodynamics of protein functions such as the binding of ligands. The observed role for conformational entropy in modulating molecular recognition by proteins is in opposition to an often-invoked theory for the interaction of protein molecules with solvent water. The "solvent slaving" model predicts that protein motion is strongly coupled to various aspects of water such as bulk solvent viscosity and local hydration shell dynamics. Changes in conformational entropy are manifested in alterations of fast internal side chain motion that is detectable by NMR relaxation. We show here that the fast-internal side …
The Crisis Of Communication In The Information Age: Revisiting C.P. Snow's Two Cultures In The Era Of Fake News, Aaron Green
The Crisis Of Communication In The Information Age: Revisiting C.P. Snow's Two Cultures In The Era Of Fake News, Aaron Green
Irish Communication Review
The purpose of this paper is to revisit C.P. Snow’s “Two Cultures” lecture in light of the cultural dominance of information technology. The crisis of communication in the information age, whether in fake news, political polarisation or science denial, has come about because both scientific and literary cultures, in seeking a world without entropy, have inadvertently stumbled upon a world without meaning. In order to explain how this has happened, the paper first explores Snow's challenge: to describe the second law of thermodynamics. The paper then provides a description of entropy that is neutral with regard to thermodynamics and information, …
Measuring And Modeling Information Flow On Social Networks, Tyson Charles Pond
Measuring And Modeling Information Flow On Social Networks, Tyson Charles Pond
Graduate College Dissertations and Theses
With the rise of social media, researchers have become increasingly interested in understanding how individuals inform, influence, and interact with others in their social network and how the network mediates the flow of information. Previous research on information flow has primarily used models of contagion to study the adoption of a technology, propagation of purchase recommendations, or virality of online activity. Social (or "complex") contagions spread differently than biological ("simple") contagions. A limitation when researchers validate contagion models is that they neglect much of the massive amounts of data now available through online social networks. Here we model a recently …