Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Publication
Articles 1 - 2 of 2
Full-Text Articles in Physics
Mechanobiology As A Tool For Addressing The Genotype-To- Phenotype Problem In Microbiology, Merrill E. Asp, Minh-Tri Ho Thanh, Subarna Dutta, Jessica A. Comstock, Roy D. Welch, Alison E. Patteson
Mechanobiology As A Tool For Addressing The Genotype-To- Phenotype Problem In Microbiology, Merrill E. Asp, Minh-Tri Ho Thanh, Subarna Dutta, Jessica A. Comstock, Roy D. Welch, Alison E. Patteson
Physics - All Scholarship
The central hypothesis of the genotype–phenotype relationship is that the phenotype of a developing organism (i.e., its set of observable attributes) depends on its genome and the environment. However, as we learn more about the genetics and biochemistry of living systems, our understanding does not fully extend to the complex multiscale nature of how cells move, interact, and organize; this gap in understanding is referred to as the genotype-to-phenotype problem. The physics of soft matter sets the background on which living organisms evolved, and the cell environment is a strong determinant of cell phenotype. This inevitably leads to challenges as …
Fabrication And Characterisation Of Large Area, Uniform And Controllable Surface Relief Patterns In Photopolymer Material, Owen Kearney, Izabela Naydenova
Fabrication And Characterisation Of Large Area, Uniform And Controllable Surface Relief Patterns In Photopolymer Material, Owen Kearney, Izabela Naydenova
Conference Papers
As the risk of antibiotic resistant pathogens increases, development of convenient point of care devices is essential. Such devices would help avoid infection – ensure cleanliness of environments and assist in bacteria analysis. The ultimate aim of the research presented here is to develop a compact, cost effective, easy to use optical device which is capable of detecting and quantifying bacteria in an aqueous sample. The surface relief patterns have a dual role, they provide a diffracted light signal, and control the adhesion of the bacteria to the surface. The strength of the diffracted signal is expected to provide a …