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Identification And Characterization Of Bisbenzimide Compounds That Inhibit Human Cytomegalovirus Replication, Nicole Falci Finardi, Hyeongjun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang
Identification And Characterization Of Bisbenzimide Compounds That Inhibit Human Cytomegalovirus Replication, Nicole Falci Finardi, Hyeongjun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang
Physics and Astronomy Faculty Publications and Presentations
The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit HCMV replication. Of these compounds, we selected bisbenzimide compound RO-90-7501 for further study. We generated analogues of RO-90-7501 and found that one compound, MRT00210423, had increased anti-HCMV activity compared to RO-90-7501. Using a combination of compound analogues, microscopy and biochemical assays we found RO-90-7501 and MRT00210423 interacted with DNA. In single molecule microscopy experiments we found RO-90-7501, but not MRT00210423, was able to compact DNA, …