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Inhibition Of The Aminopeptidase From Aeromonas Proteolytica By L-Leucinephosphonic Acid, A Transition State Analogue Of Peptide Hydrolysis, Brian Bennett, Richard C. Holz
Inhibition Of The Aminopeptidase From Aeromonas Proteolytica By L-Leucinephosphonic Acid, A Transition State Analogue Of Peptide Hydrolysis, Brian Bennett, Richard C. Holz
Physics Faculty Research and Publications
No abstract provided.
Proton Nmr Spectroscopy As A Probe Of Dinuclear Copper(Ii) Active Sites In Metalloproteins. Characterization Of The Hyperactive Copper(Ii)-Substituted Aminopeptidase From Aeromonas Proteolytica, Richard C. Holz, Brian Bennett, Guanjing Chen, Li-June Ming
Proton Nmr Spectroscopy As A Probe Of Dinuclear Copper(Ii) Active Sites In Metalloproteins. Characterization Of The Hyperactive Copper(Ii)-Substituted Aminopeptidase From Aeromonas Proteolytica, Richard C. Holz, Brian Bennett, Guanjing Chen, Li-June Ming
Physics Faculty Research and Publications
Proton NMR spectra of the hyperactive Cu(II)-substituted aminopeptidase from Aeromonas proteolytica (AAP) were recorded in both H2O and D2O buffered solution at pH 6.7. Several remarkably sharp, well resolved hyperfine shifted 1H NMR signals were observed in the 70 to −20 ppm chemical shift range. That hyperfine shifted signals were observed is due to spin-coupling of the two Cu(II) ions. Comparison of the spectra recorded in H2O and D2O buffered solutions indicated that the signals at 44.6, 43.3, and 17.7 ppm were solvent exchangeable. The two most strongly downfield shifted signals …
Synthesis, Molecular Structure, And Reactivity Of Dinuclear Copper(Ii) Complexes With Carboxylate-Rich Coordination Environments, Richard C. Holz, John M. Bradshaw, Brian Bennett
Synthesis, Molecular Structure, And Reactivity Of Dinuclear Copper(Ii) Complexes With Carboxylate-Rich Coordination Environments, Richard C. Holz, John M. Bradshaw, Brian Bennett
Physics Faculty Research and Publications
The dinucleating ligand N,N‘-(2-hydroxy-5-methyl-1,3-xylylene)bis(N-(carboxymethyl)glycine) (CH3HXTA) has been used to synthesize the dinuclear Cu(II) bis(pyridine) complex Na[Cu2(CH3HXTA)(Py)2]·1.5(1,4-dioxane) (Na(1)): triclinic space group P1̄ (a = 12.550(3) Å, b = 13.413(3) Å, c = 13.540(4) Å, α = 117.12(2)°, β = 104.70 (2)°, and γ = 92.13(2)°). The structure shows two distinct distorted square pyramidal Cu(II) centers with each Cu(II) ion bound by two carboxylate oxygen atoms, one amine nitrogen atom, a phenolate oxygen atom, and one pyridine nitrogen atom. The Cu--Cu separation is 3.531 Å, …