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Extracellular Vimentin Is Sufficient To Promote Cell Attachment, Spreading, And Motility By A Mechanism Involving N-Acetyl Glucosamine-Containing Structures, Robert Bucki, Daniel V. Iwamoto, Xuechen Shi, Katherine E. Kerr, Fitzroy J. Byfield, Lukasz Suprewicz, Karol Sklodowski, Julian Sutaria, Pawel Misiak, Agnieszka Z. Wilczewska, Sekar Ramachandran, Aaron Wolfe, Minh H. Thanh, Eli Whalen, Alison E. Patteson, Paul A. Janmey
Extracellular Vimentin Is Sufficient To Promote Cell Attachment, Spreading, And Motility By A Mechanism Involving N-Acetyl Glucosamine-Containing Structures, Robert Bucki, Daniel V. Iwamoto, Xuechen Shi, Katherine E. Kerr, Fitzroy J. Byfield, Lukasz Suprewicz, Karol Sklodowski, Julian Sutaria, Pawel Misiak, Agnieszka Z. Wilczewska, Sekar Ramachandran, Aaron Wolfe, Minh H. Thanh, Eli Whalen, Alison E. Patteson, Paul A. Janmey
Physics - All Scholarship
Vimentin intermediate !laments form part of the cytoskeleton
of mesenchymal cells, but under pathological conditions often
associatedwith in"ammation, vimentin !laments depolymerize as
the result of phosphorylation or citrullination, and vimentin
oligomers are secreted or released into the extracellular environment.
In the extracellular space, vimentin can bind surfaces of cells
and the extracellular matrix, and the interaction between extracellular
vimentin and cells can trigger changes in cellular functions,
such as activation of !broblasts to a !brotic phenotype. The
mechanism by which extracellular vimentin binds external cell
membranes and whether vimentin alone can act as an adhesive
anchor for cells is largely …