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The Conformational Gymnastics Of The Escherichia Coli Seca Molecular Machine And Its Interactions With Signal Sequences, Jenny Lynn Maki
The Conformational Gymnastics Of The Escherichia Coli Seca Molecular Machine And Its Interactions With Signal Sequences, Jenny Lynn Maki
Open Access Dissertations
Protein secretion is a selective and regulated process that is essential in all organisms. In bacteria the preprotein translocase SecA, either free in the cytosol or associated with the SecYEG translocon, recognizes and binds most post-translational secretory proteins containing an N-terminal signal sequence. In Gram-negative bacteria, the molecular chaperone SecB binds many of the preproteins to keep them in a translocation-competent state. Subsequently, SecB delivers the preproteins to the translocon-associated SecA, which binds the signal sequence and also interacts with mature regions of the preprotein. After the preprotein/SecA/SecYEG complex has formed, the energy derived from ATP hydrolysis by SecA coupled …