Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physics
Polynitroxylated Pegylated Hemoglobin: A Novel Neuroprotective Hemoglobin For Acute Volume-Limited Fluid Resuscitation After Combined Traumatic Brain Injury And Hemorrhagic Hypotension In Mice, David K. Shellington, Lina Du, Xianren Wu, Jennifer Exo, Vincent A. Vagni, Li Ma, Keri Janesko-Feldman, Robert S. B. Clark, Hülya Bayır, C. Edward Dixon, Larry W. Jenkins, Carleton J. C. Hsia, Patrick M. Kochanek
Polynitroxylated Pegylated Hemoglobin: A Novel Neuroprotective Hemoglobin For Acute Volume-Limited Fluid Resuscitation After Combined Traumatic Brain Injury And Hemorrhagic Hypotension In Mice, David K. Shellington, Lina Du, Xianren Wu, Jennifer Exo, Vincent A. Vagni, Li Ma, Keri Janesko-Feldman, Robert S. B. Clark, Hülya Bayır, C. Edward Dixon, Larry W. Jenkins, Carleton J. C. Hsia, Patrick M. Kochanek
Department of Physics and Astronomy Faculty Publications
Objective: Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The novel therapeutic hemoglobin-based oxygen carrier, polynitroxylated pegylated hemoglobin (PNPH), may represent a neuroprotective hemoglobin-based oxygen carrier for traumatic brain injury resuscitation.
Hypotheses: 1) PNPH is a unique non-neurotoxic hemoglobin-based oxygen carrier in neuronal culture and is neuroprotective in in vitro neuronal injury models. 2) Resuscitation with PNPH would require less volume to restore mean arterial blood pressure than lactated Ringer's or Hextend and confer neuroprotection in a mouse model of traumatic brain injury plus hemorrhagic hypotension.
Design: Prospective randomized, controlled experimental …