Physics Commons^™

The Journey Of A Single Polymer Chain To A Nanopore, Navid Afrasiabian

Electronic Thesis and Dissertation Repository

Single chain translocation has been eagerly studied for more than two decades due to its importance in biological processes and also, providing a better understanding of polymer dynamics. Polymer translocation can be divided into three stages of reaching the pore, entering the pore and passing through it. We study the delivery of the chain from the bulk to the entrance, which is called the capture process, for a single chain driven by hydrodynamic flow. Our molecular dynamics-lattice Boltzmann simulations show that the converging flow around the nanopore not only facilitates the process of finding the pore but also deforms the …

Studying Resting State And Stimulus Induced Bold Activity Using The Generalized Ising Model And Independent Component Graph Analysis, Sivayini Kandeepan

Electronic Thesis and Dissertation Repository

Although many technical advancements have been made, neuroscientists still struggle to explain the underlying behaviour of how brain regions communicate with each other to form large-scale functional networks. functional Magnetic Resonance Imaging (fMRI) has been commonly used to investigate changes between brain regions over time using the Blood Oxygen Level Dependent (BOLD) signal.

The goal of this thesis is to show the applicability of novel techniques and tools, such as the generalized Ising model (GIM) and the independent component graph analysis (GraphICA), to obtain information on the functional connectivity of populations with altered perception of consciousness. The GIM was used …