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Development Of Novel Intracavitary Intensity Modulated Brachytherapy Applicators For Optimizing The Target Coverage In Gynecologic Malignancies, Monte Carlo Simulation Dosimetry, Moeen Meftahi
Theses and Dissertations
Gynecologic brachytherapy (GYN-BT) is essential for treating cervical and endometrial cancers, the most prevalent female reproductive cancers. This technique enables high radiation doses to a target with rapid dose fall-off to protect adjacent healthy organs. This dissertation aims to address some of the limitations of intracavitary GYN-BT using an intensity modulated brachytherapy (IMBT) technique and Monte Carlo (MC) simulations.
First, a novel non-invasive shielded vaginal cylinder (VC) applicator was designed to provide optimized radiation coverage for the target volume at vaginal apex, site of most recurrences without BT, for endometrial cancer BT. Physical limitations of current applicators and their resulting …