Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physics
Identification Of Receptor Ligands In Apo B100 Reveals Potential Functional Domains, Juan Guevara Jr., Jamie Romo Jr., Ernesto Hernandez, Natalia Valentinova Guevara
Identification Of Receptor Ligands In Apo B100 Reveals Potential Functional Domains, Juan Guevara Jr., Jamie Romo Jr., Ernesto Hernandez, Natalia Valentinova Guevara
Physics and Astronomy Faculty Publications and Presentations
LDL, VLDL and other members of the low-density lipoparticles (LLPs) enter cells through a large family of receptors. The actual receptor ligand(s) in apolipoprotein B100, one of the main proteins of LLP, remain(s) unknown. The objective of this study was to identify true receptor ligand(s) in apo B100, a molecule of 4,563 residues. Apo B100 contains 33 analogues of Cardin-Weintraub Arginine/Lysine-based receptor ligand motifs and shares key Lysine motifs and sequence similarity with the LDL receptor-associated protein, RAP, MESD, and heat shock proteins. Eleven FITC-labeled synthetic peptides of 21 – 42 residues, with at least one ligand, were tested for …