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- Blood-Brain Barrier (1)
- Blood-Brain Barrier Disruption (1)
- FMRI (1)
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- Freestanding metal nanomembrane (1)
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- High field (1)
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Articles 1 - 3 of 3
Full-Text Articles in Physics
Advances In Image Acquisition And Filtering For Mri Neuroimaging At 7 Tesla, Andrew T. Curtis
Advances In Image Acquisition And Filtering For Mri Neuroimaging At 7 Tesla, Andrew T. Curtis
Electronic Thesis and Dissertation Repository
Performing magnetic resonance imaging at high magnetic field strength promises many improvements over low fields that are of direct benefit in functional neuroimaging. This includes the possibility of improved signal-to-noise levels, and increased BOLD functional contrast and spatial specificity. However, human MRI at 7T and above suffers from unique engineering challenges that limit the achievable gains. In this thesis, three technological developments are introduced, all of which address separate issues associated with functional magnetic resonance neuroimaging at very high magnetic field strengths.
First, the image homogeneity problem is addressed by investigating methods of RF shimming — modifying the excitation portion …
Plasmonic Optical Sensors: Performance Analysis And Engineering Towards Biosensing, Peipei Jia
Plasmonic Optical Sensors: Performance Analysis And Engineering Towards Biosensing, Peipei Jia
Electronic Thesis and Dissertation Repository
Surface plasmon resonance (SPR) sensing for quantitative analysis of chemical reactions and biological interactions has become one of the most promising applications of plasmonics. This thesis focuses on performance analysis for plasmonic sensors and implementation of plamonic optical sensors with novel nanofabrication techniques.
A universal performance analysis model is established for general two-dimensional plasmonic sensors. This model is based on the fundamental facts of surface plasmon theory. The sensitivity only depends on excitation light wavelength as well as dielectric properties of metal and dielectrics. The expression involves no structure-specified parameters, which validates this formula in broad cases of periodic, quasiperiodic …
A Non-Contrast Magnetic Resonance Imaging Technique To Assess Blood-Brain Barrier Permeability, Harini Pandithasekera
A Non-Contrast Magnetic Resonance Imaging Technique To Assess Blood-Brain Barrier Permeability, Harini Pandithasekera
Electronic Thesis and Dissertation Repository
The Blood-brain barrier (BBB) regulates the entry of compounds between the blood and the brain, thus plays an important role in brain homeostasis. Studies indicate in disease states such as Alzheimer’s the BBB integrity is compromised. The motive of this project is to investigate the sensitivity of the diffusion-weighted arterial spin labeling (DW-ASL) technique to detect water exchange. Testing the sensitivity requires a reliable method of opening the barrier at specific locations of the brain. Here, a unique technology named focused ultrasound (FUS) has been used to mimic a compromised BBB environment.
A series of experiments were conducted in a …