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Biosynthesis, Characterization And Antiproliferative Activity Of Green Synthesized Gold Nanoparticles Using Lantadene A Extracted From Lantana Camara, Dawood Ali Salim Dawood, Lee Suan Chua Ph.D, Tian Swee Tan Ph.D, Ahmed F. Alshemary Ph.D
Biosynthesis, Characterization And Antiproliferative Activity Of Green Synthesized Gold Nanoparticles Using Lantadene A Extracted From Lantana Camara, Dawood Ali Salim Dawood, Lee Suan Chua Ph.D, Tian Swee Tan Ph.D, Ahmed F. Alshemary Ph.D
Karbala International Journal of Modern Science
This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 µg/mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP