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Full-Text Articles in Physics
Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana
Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana
KGI Theses and Dissertations
Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …
Examination Of Flow Dynamics And Passive Cooling In An Ultra Compact Combustor, Tylor C. Rathsack
Examination Of Flow Dynamics And Passive Cooling In An Ultra Compact Combustor, Tylor C. Rathsack
Theses and Dissertations
The Ultra Compact Combustor (UCC) promises to greatly reduce the size of a gas turbine engine’s combustor by altering the manner in which fuel is burnt. Differing from the common axial flow combustor, the UCC utilizes a rotating flow, coaxial to the engine’s primary axis, in an outboard circumferential cavity as the primary combustion zone. The present study investigates two key UCC facets required to further this combustor design. The first area of investigation is cooling of the Hybrid Guide Vane (HGV). This UCC specific hardware acts as a combustor center body that alters the exit flow angle and acts …