Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aggregation (1)
- Alcoholic liver disease (1)
- Amyloid (1)
- Beta sheet (1)
- Biophysics (1)
-
- Biosensors (1)
- Electroactive (1)
- Extracellular matrix (1)
- Fibril (1)
- Huntington's disease (1)
- Innate immunity (1)
- Liver injury (1)
- Macrophages (1)
- MaxCal (1)
- Metadynamics (1)
- Modeling (1)
- Molecular dynamics (1)
- Morphology (1)
- Peptide structure (1)
- Physics and Astronomy (1)
- PolyQ (1)
- Polyglutamine (1)
- Protein (1)
- STED (1)
- Spectroelectrochemistry (1)
- Stochasticity (1)
- Tumor modeling (1)
- Waveguide (1)
Articles 1 - 4 of 4
Full-Text Articles in Physics
Innate Immunity, The Hepatic Extracellular Matrix, And Liver Injury: Mathematical Modeling Of Metastatic Potential And Tumor Development In Alcoholic Liver Disease., Shanice V. Hudson
Innate Immunity, The Hepatic Extracellular Matrix, And Liver Injury: Mathematical Modeling Of Metastatic Potential And Tumor Development In Alcoholic Liver Disease., Shanice V. Hudson
Electronic Theses and Dissertations
The overarching goals of the current work are to fill key gaps in the current understanding of alcohol consumption and the risk of metastasis to the liver. Considering the evidence this research group has compiled confirming that the hepatic matrisome responds dynamically to injury, an altered extracellular matrix (ECM) profile appears to be a key feature of pre-fibrotic inflammatory injury in the liver. This group has demonstrated that the hepatic ECM responds dynamically to alcohol exposure, in particular, sensitizing the liver to LPS-induced inflammatory damage. Although the study of alcohol in its role as a contributing factor to oncogenesis and …
Structure And Thermodynamics Of Polyglutamine Peptides And Amyloid Fibrils Via Metadynamics And Molecular Dynamics Simulations, Riley Workman
Structure And Thermodynamics Of Polyglutamine Peptides And Amyloid Fibrils Via Metadynamics And Molecular Dynamics Simulations, Riley Workman
Electronic Theses and Dissertations
Aggregation of polyglutamine (polyQ)-rich polypeptides in neurons is a marker for nine neurodegenerative diseases. The molecular process responsible for the formation of polyQ fibrils is not well understood and represents a growing area of study. To enable development of treatments that could interfere with aggregation of polyQ peptides, it is crucial to understand the molecular mechanisms by which polyQ peptides aggregate into fibrils. Many experimental techniques have been employed to probe polyQ aggregation, however, observations from these studies have not lead to a unified understanding of the properties of these systems, instead yielding competing, fragmented theories of polyQ aggregation. This …
Photonic Tools For Advanced Sensing And Imaging At The Nanoscale., Jafar Hamed Ghithan
Photonic Tools For Advanced Sensing And Imaging At The Nanoscale., Jafar Hamed Ghithan
Electronic Theses and Dissertations
This dissertation reports a novel bio-sensing strategy based on single-mode, electro-active, integrated optical waveguide (SM-EA-IOW) platforms. It also reports the development of a super-resolved far-field optical imaging tool to enable optical, electronic, and spectroelectrochemical investigations at the nanoscale. SM-EA-IOW platforms with its outstanding sensitivity for spectroelectrochemical interrogation was combined with a sandwich bioassay for the development of a novel immunosensing based strategy for label-free detection of infectious pathogens. The strategy begins with the functionalization of the electroactive waveguide surface with a capturing antibody aimed at a specific target analyte. Once the target analyte is bound to the photonic interface, it …
Learning From Disorder And Noise In Physical Biology, Taylor Emil Firman
Learning From Disorder And Noise In Physical Biology, Taylor Emil Firman
Electronic Theses and Dissertations
Stochasticity, disorder, and noise play crucial roles in the functioning of many biological systems over many different length scales. On the molecular scale, most proteins are envisioned as pristinely folded structures, but intrinsically disordered proteins (IDPs) have no such folded state and still serve distinct purposes within the cell. At the scale of gene regulation, realistic in vivo conditions produce stochastic fluctuations in gene expression that can lead to advantageous bet-hedging strategies, but can be difficult to characterize using a deterministic framework. Even at the organismal scale, germband extension (GBE) in Drosophila melanogaster embryos systematically elongates the epithelial tissue using …